Detailed information of TA system TA050234

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /COG5642-COG5654
• Location: 357119..358109
• Replicon: chromosome
• Accession: NZ_CP009997
• Organism: Yersinia kristensenii strain Y231

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A386HEZ3
• Locus tag: CH54_RS01650
• Protein ID: WP_038632724.1
• Coordinates: 357119..357577 (-)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A386HEX0
• Locus tag: CH54_RS01655
• Protein ID: WP_038632726.1
• Coordinates: 357663..358109 (-)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CH54_RS01620	352990..353655	+	666	WP_038632711.1	phage shock protein PspA	-
CH54_RS01625	353760..353987	+	228	WP_038632713.1	envelope stress response membrane protein PspB	-
CH54_RS01630	354041..354391	+	351	WP_038639499.1	envelope stress response membrane protein PspC	-
CH54_RS01635	354437..354676	+	240	WP_038632715.1	phage shock protein PspD	-
CH54_RS01640	354657..356054	+	1398	WP_038632717.1	YcjX family protein	-
CH54_RS01645	356051..357112	+	1062	WP_038632723.1	YcjF family protein	-
CH54_RS01650	357119..357577	-	459	WP_038632724.1	RES family NAD+ phosphorylase	Toxin
CH54_RS01655	357663..358109	-	447	WP_038632726.1	DUF2384 domain-containing protein	Antitoxin
CH54_RS01660	358429..360006	+	1578	WP_038632728.1	transcriptional regulator TyrR	-
CH54_RS01665	360167..360670	-	504	WP_038632730.1	thiol peroxidase	-
CH54_RS01670	360822..361793	+	972	WP_038632732.1	L-Ala-D/L-Glu epimerase	-
CH54_RS01675	361790..362497	-	708	WP_038632734.1	murein tripeptide amidase MpaA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (2-147)

Antitoxin

• Antitoxin Xre (15-148)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 17292.75 Da
• Isoelectric Point: 5.1666

>T50234 WP_038632724.1 NZ_CP009997:c357577-357119 [Yersinia kristensenii]
MKFYRIVMRRYLASTWTGYGAEIYGGRWNHKGHAAIYLASSVSLAMLETLVHIQDSSTLSEFELFQIEIEDSHILLLQPQ
DWPADWRSDPAPATTMDIGTEWLELESSLALLVPSTLVPSENNLLLNPRHKDFQACLNSVKPLSFAFDPRLK

Nucleotide

• Length: 459 bp

>T50234 NZ_CP009997:c357577-357119 [Yersinia kristensenii]
ATGAAGTTCTACCGTATTGTGATGCGCCGTTATCTGGCGTCAACCTGGACCGGTTATGGCGCCGAAATCTATGGTGGCCG
TTGGAATCATAAGGGGCACGCCGCCATCTACTTAGCCAGCAGTGTGTCTTTGGCGATGCTGGAAACATTGGTACATATCC
AAGATAGCTCAACGCTGAGCGAGTTCGAGCTATTCCAGATTGAAATCGAAGATAGCCATATTCTGTTACTTCAACCGCAA
GATTGGCCTGCTGACTGGCGCAGTGATCCCGCACCGGCGACCACAATGGATATCGGCACCGAATGGTTAGAGCTGGAATC
ATCACTTGCATTACTGGTTCCATCCACTCTGGTGCCGTCAGAAAACAATCTACTGCTCAACCCTCGGCATAAAGATTTTC
AAGCTTGCTTAAACAGTGTTAAACCACTCTCTTTTGCCTTTGACCCACGGCTGAAATAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16177.61 Da
• Isoelectric Point: 9.1260

>AT50234 WP_038632726.1 NZ_CP009997:c358109-357663 [Yersinia kristensenii]
MRAYHPTPATKTGALWREIGLPASRGTVLVDSIKMGFSVDVIDGIHLWASIPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAIAWMSTPIKGLGHRSPDSLLETETGALEVCDLIGRLEHGVFS

Nucleotide

• Length: 447 bp

>AT50234 NZ_CP009997:c358109-357663 [Yersinia kristensenii]
ATGAGAGCATATCACCCGACCCCAGCGACCAAAACTGGGGCGCTATGGCGAGAGATTGGTTTGCCCGCCAGCCGCGGCAC
TGTATTGGTCGATAGTATCAAAATGGGTTTTTCAGTTGATGTCATCGACGGTATCCATTTATGGGCTTCTATCCCTAAAG
CTGAAATATTGCGGGCCACGGGTATTCCCAGCCGCAGTCTGACCCGCAGACGCACACATGATGGCCGTTTCACCCCTGAA
GAGAGTGAGCGAATTGCCCGTTTCGTCCGGGTAATGGATGCCGCAGTTGATCTATTTGGCGGTGATAAGGGCAAAGCTAT
CGCCTGGATGTCTACCCCGATTAAAGGTCTTGGTCACCGCAGCCCCGACTCCTTGCTGGAAACGGAAACCGGTGCACTGG
AAGTCTGTGATTTAATTGGGCGTTTGGAGCACGGTGTATTTTCATAA