Detailed information of TA system TA050233

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 193312..193825
• Replicon: chromosome
• Accession: NZ_CP009997
• Organism: Yersinia kristensenii strain Y231

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A386HFI9
• Locus tag: CH54_RS00870
• Protein ID: WP_038632447.1
• Coordinates: 193312..193596 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A386HFF3
• Locus tag: CH54_RS00875
• Protein ID: WP_012105237.1
• Coordinates: 193586..193825 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CH54_RS00840	188912..189145	-	234	WP_038632437.1	DNA polymerase III subunit theta	-
CH54_RS00845	189539..190048	+	510	WP_038632439.1	non-heme ferritin	-
CH54_RS00850	190438..190824	+	387	WP_038632441.1	CopC domain-containing protein YobA	-
CH54_RS00855	190826..191710	+	885	WP_038632443.1	copper homeostasis membrane protein CopD	-
CH54_RS00860	191807..192148	+	342	WP_038632445.1	YebY family protein	-
CH54_RS00865	192674..193301	+	628	Protein_175	terminase small subunit	-
CH54_RS00870	193312..193596	-	285	WP_038632447.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CH54_RS00875	193586..193825	-	240	WP_012105237.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
CH54_RS21155	193952..194122	+	171	WP_187142909.1	hypothetical protein	-
CH54_RS00880	194405..195568	-	1164	WP_071841717.1	class C beta-lactamase	-
CH54_RS00885	195837..196709	+	873	WP_038632453.1	23S rRNA pseudouridine(2604) synthase RluF	-
CH54_RS00890	196829..198037	-	1209	WP_038632455.1	sodium/glutamate symporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	186728..199205	12477

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (2-76)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11172.92 Da
• Isoelectric Point: 10.1967

>T50233 WP_038632447.1 NZ_CP009997:c193596-193312 [Yersinia kristensenii]
MTYNLDFDRRALKEWHKLGDTVRQQFKKKLLEVIKNPRVEANKLRDLPDCYKIKLRSAGYRLIYQVQDEKITVFVVAVGK
RDREEAYSEAGNRV

Nucleotide

• Length: 285 bp

>T50233 NZ_CP009997:c193596-193312 [Yersinia kristensenii]
ATGACTTATAATCTTGATTTTGATCGCCGGGCGCTAAAGGAATGGCATAAGCTCGGCGATACCGTACGCCAGCAATTTAA
GAAAAAGTTGCTCGAAGTGATTAAAAATCCACGCGTTGAAGCCAATAAACTGCGCGACTTACCTGATTGTTACAAAATAA
AACTACGCAGCGCCGGATACCGCCTGATTTATCAGGTGCAAGACGAAAAAATCACGGTTTTTGTGGTTGCCGTGGGTAAA
CGGGATCGTGAAGAAGCCTACAGTGAAGCTGGCAATCGCGTCTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8836.12 Da
• Isoelectric Point: 4.5105

>AT50233 WP_012105237.1 NZ_CP009997:c193825-193586 [Yersinia kristensenii]
MGNINIRIDDDLKDRSYAVLEKLGVTPSDLLRQTLEYVAQSGKLPFKSVLLTDEDQALVAVVRERLANPQPVRVSLDDL

Nucleotide

• Length: 240 bp

>AT50233 NZ_CP009997:c193825-193586 [Yersinia kristensenii]
ATGGGTAACATTAATATTCGCATTGATGATGACTTAAAAGATCGTTCTTATGCGGTACTGGAAAAGCTGGGGGTCACCCC
CTCTGATTTGCTGCGCCAGACACTGGAATATGTGGCACAAAGTGGCAAACTGCCCTTTAAATCCGTGTTGCTGACCGATG
AAGATCAAGCACTGGTCGCCGTAGTCAGAGAACGTTTAGCCAATCCACAACCGGTCAGGGTGTCACTGGATGACTTATAA