Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 4356831..4357477 Replicon chromosome
Accession NZ_CP009991
Organism Yersinia pestis strain Nicholisk 41

Toxin (Protein)


Gene name hicA Uniprot ID A0A3G5L3F2
Locus tag CH63_RS21100 Protein ID WP_002214976.1
Coordinates 4357295..4357477 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0U1R391
Locus tag CH63_RS21095 Protein ID WP_002211129.1
Coordinates 4356831..4357250 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH63_RS21075 4351903..4352898 + 996 WP_002211125.1 substrate-binding domain-containing protein -
CH63_RS21080 4352964..4354541 + 1578 WP_002211126.1 sugar ABC transporter ATP-binding protein -
CH63_RS21085 4354544..4355565 + 1022 Protein_3764 ABC transporter permease -
CH63_RS21090 4355614..4356573 + 960 WP_002223882.1 sugar kinase -
CH63_RS21095 4356831..4357250 - 420 WP_002211129.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CH63_RS21100 4357295..4357477 - 183 WP_002214976.1 type II toxin-antitoxin system HicA family toxin Toxin
CH63_RS21105 4357684..4358466 - 783 WP_002211130.1 flagellar type III secretion system protein FliR -
CH63_RS21110 4358469..4358738 - 270 WP_002211131.1 flagellar biosynthesis protein FliQ -
CH63_RS21115 4358844..4359584 - 741 WP_002220494.1 flagellar type III secretion system pore protein FliP -
CH63_RS21120 4359665..4360201 - 537 WP_002211133.1 flagellar biosynthetic protein FliO -
CH63_RS21125 4360201..4360617 - 417 WP_002211134.1 flagellar motor switch protein FliN -
CH63_RS21130 4360614..4361615 - 1002 WP_002211135.1 flagellar motor switch protein FliM -
CH63_RS21135 4361621..4362091 - 471 WP_002227961.1 flagellar basal body-associated protein FliL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-131)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6783.99 Da        Isoelectric Point: 10.8877

>T50224 WP_002214976.1 NZ_CP009991:c4357477-4357295 [Yersinia pestis]
VKSSELIKLLETNGWKLMRVKGSHHQFKHPDFAAVITVPHPKKDVKPGTLRQILKDANLS

Download         Length: 183 bp

>T50224 NZ_CP009991:c4357477-4357295 [Yersinia pestis]
GTGAAAAGTTCGGAGCTGATAAAACTGCTCGAAACAAATGGTTGGAAGTTGATGAGAGTTAAAGGCAGTCATCATCAATT
CAAACATCCTGATTTCGCGGCAGTCATAACAGTACCGCATCCCAAAAAGGATGTTAAACCGGGAACCCTCCGGCAAATTC
TGAAAGATGCAAACCTTAGTTAA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15549.42 Da        Isoelectric Point: 4.7731

>AT50224 WP_002211129.1 NZ_CP009991:c4357250-4356831 [Yersinia pestis]
MAIYPAYVHVDNDGSASGYFPDVKGCIFAINAGEDLFAEASSALDAHFEALVSEGIEIPEAHDMPYHVYRNPCDYADGGQ
WYNVNIDMSKYDGKVERINVTLPHRLIHQIDTIVKVRPEYASRSNFLAEAARKELQKLA

Download         Length: 420 bp

>AT50224 NZ_CP009991:c4357250-4356831 [Yersinia pestis]
ATGGCTATCTATCCCGCCTATGTTCACGTTGATAATGATGGCTCGGCAAGCGGTTATTTCCCCGATGTCAAAGGCTGTAT
TTTTGCCATCAATGCCGGGGAGGATTTATTTGCAGAAGCATCAAGCGCCCTGGATGCACACTTTGAAGCTTTGGTGTCTG
AAGGTATCGAAATTCCTGAAGCTCATGACATGCCTTACCACGTTTACCGTAACCCATGCGATTACGCTGATGGCGGACAG
TGGTATAACGTGAATATTGATATGTCGAAATATGATGGAAAAGTTGAACGAATTAACGTCACTCTTCCGCACCGGCTGAT
TCATCAAATCGATACTATTGTTAAAGTGCGTCCCGAGTATGCCAGCCGAAGCAATTTTCTAGCCGAAGCAGCACGTAAAG
AATTACAGAAATTGGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G5L3F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1R391

References