Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3439563..3440183 Replicon chromosome
Accession NZ_CP009991
Organism Yersinia pestis strain Nicholisk 41

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag CH63_RS16820 Protein ID WP_002208622.1
Coordinates 3439563..3439766 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q66DR4
Locus tag CH63_RS16825 Protein ID WP_002218472.1
Coordinates 3439815..3440183 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH63_RS16795 3434585..3434923 + 339 WP_002208627.1 P-II family nitrogen regulator -
CH63_RS16800 3434963..3436252 + 1290 WP_002228344.1 ammonium transporter AmtB -
CH63_RS16805 3436512..3437372 - 861 WP_002208625.1 acyl-CoA thioesterase II -
CH63_RS16810 3437629..3438150 + 522 WP_002208624.1 lipoprotein -
CH63_RS16815 3438286..3438675 - 390 WP_002208623.1 MGMT family protein -
CH63_RS16820 3439563..3439766 - 204 WP_002208622.1 expression modulating protein YmoA Toxin
CH63_RS16825 3439815..3440183 - 369 WP_002218472.1 Hha toxicity modulator TomB Antitoxin
CH63_RS16830 3440342..3440695 - 354 WP_002208619.1 hypothetical protein -
CH63_RS16835 3441569..3441712 - 144 WP_002208618.1 type B 50S ribosomal protein L36 -
CH63_RS16840 3441728..3441988 - 261 WP_002208617.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T50215 WP_002208622.1 NZ_CP009991:c3439766-3439563 [Yersinia pestis]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T50215 NZ_CP009991:c3439766-3439563 [Yersinia pestis]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATCGATACGCTAGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGATGATGAACTGGAATTGTTTTACTCAGCTGCAGACCATCGCCTGGCTGAACTAACGATGAATAAGC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14215.00 Da        Isoelectric Point: 4.6121

>AT50215 WP_002218472.1 NZ_CP009991:c3440183-3439815 [Yersinia pestis]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWINDPTSAINLQLNDLIEHIASFVMSFKIKYPDGSQLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKEHLFRLFSGEYVCTLMKT

Download         Length: 369 bp

>AT50215 NZ_CP009991:c3440183-3439815 [Yersinia pestis]
ATGGATGAGTACTCGCCTAAGCGGCATGACATTGCCCAACTGAAGTTTCTATGTGAAAGCTTGTATGATGAAGGTATTGC
AACTCTTGGCGACAGCCATCATGGCTGGATAAATGACCCAACGTCGGCCATAAACCTTCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGGAAGCCAGCTTTCCGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGTAGTTATGGAATCAATGATCCTGAATTGCGTCGCTGGCAGAAAACCAAAGAGCATTT
ATTCAGACTTTTCTCAGGGGAATACGTATGTACCCTGATGAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB Q66DR4

References