Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-CC2985
Location 163..697 Replicon plasmid 2
Accession NZ_CP009990
Organism Yersinia pestis strain Nicholisk 41

Toxin (Protein)


Gene name parE Uniprot ID Q663N8
Locus tag CH63_RS00625 Protein ID WP_002213360.1
Coordinates 163..462 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9ZGW3
Locus tag CH63_RS00630 Protein ID WP_002224342.1
Coordinates 455..697 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH63_RS00625 163..462 - 300 WP_002213360.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CH63_RS00630 455..697 - 243 WP_002224342.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
CH63_RS23615 863..1155 - 293 Protein_3 IS6 family transposase -
CH63_RS24745 1241..1414 + 174 WP_002213357.1 hypothetical protein -
CH63_RS24620 1563..1799 - 237 WP_154020274.1 hypothetical protein -
CH63_RS00640 1959..2924 - 966 WP_002213354.1 ParB/RepB/Spo0J family plasmid partition protein -
CH63_RS00645 2921..4087 - 1167 WP_002220902.1 plasmid-partitioning protein SopA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - yopK/yopQ / yopT / sycT / yopM / yopD / yopB / sycD/lcrH / lcrV / lcrG / lcrR / yscV/lcrD / yscY / yscX / sycN / tyeA / lcrE/yopN / yscN / yscO / yscP / yscQ / yscR / yscS / yscT / yscU / virG/yscW / yscB / yscC / yscC / yscD / yscE / yscF / yscG / yopR/yscH/lcrP / lcrO/yscI / ylpB/yscJ / yscK / yscL / lcrQ/yscM / yopH / yopJ/yopP / yopO/ypkA / yopO/ypkA / yadA / yadA / sycH / sycE/yerA 1..68552 68552


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

Antitoxin ParD

(5-72)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11632.19 Da        Isoelectric Point: 5.5114

>T50211 WP_002213360.1 NZ_CP009990:c462-163 [Yersinia pestis]
VYKLSELADEDIYNIASYTIRHFGVTQAKLYHENLAKVFELLAKNPELGAECNWICSDIRRFQYKKHGIYYITLSNDILI
SRVLHQSIDIDVQDFPEHE

Download         Length: 300 bp

>T50211 NZ_CP009990:c462-163 [Yersinia pestis]
GTGTATAAACTGTCTGAACTAGCTGATGAGGATATTTATAATATTGCCAGTTATACTATCCGGCATTTCGGTGTGACTCA
GGCTAAGTTATACCATGAGAACTTGGCAAAGGTATTCGAGCTATTAGCTAAAAATCCAGAGTTAGGGGCTGAGTGTAACT
GGATTTGCTCTGATATTCGCCGTTTTCAGTATAAAAAGCACGGTATATACTATATAACGCTTAGCAATGATATTTTGATT
TCTCGAGTGCTGCATCAATCCATAGATATAGATGTTCAGGATTTTCCAGAGCATGAGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8865.15 Da        Isoelectric Point: 6.4781

>AT50211 WP_002224342.1 NZ_CP009990:c697-455 [Yersinia pestis]
MAHVTSVTLGEHLTGFVGEMIQSGRYGNISEVLRDALRLMEAREQRVQHVRDMVLAGTNVPVSHRLMDEIFSAAVKDTSV

Download         Length: 243 bp

>AT50211 NZ_CP009990:c697-455 [Yersinia pestis]
ATGGCTCACGTAACCAGCGTAACACTTGGAGAGCATTTGACAGGTTTTGTGGGGGAAATGATTCAGTCTGGTCGTTATGG
CAATATATCAGAAGTGCTTCGTGATGCCTTAAGGCTAATGGAAGCACGTGAACAGCGTGTTCAACATGTACGCGATATGG
TGCTTGCAGGAACAAATGTACCTGTGAGCCATCGTTTAATGGATGAGATTTTTTCTGCTGCGGTGAAAGATACTAGTGTA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q663N8

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1NQY6

References