Detailed information of TA system TA050210

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 376422..376981
• Replicon: chromosome
• Accession: NZ_CP009985
• Organism: Vibrio vulnificus strain FORC_009

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FORC9_RS16435
• Protein ID: WP_060533350.1
• Coordinates: 376703..376981 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A3Q0L0M2
• Locus tag: FORC9_RS16430
• Protein ID: WP_011082348.1
• Coordinates: 376422..376706 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FORC9_RS16400	371964..372392	-	429	WP_060534770.1	hypothetical protein	-
FORC9_RS16405	372487..372897	-	411	WP_060533342.1	hypothetical protein	-
FORC9_RS16410	373350..374027	-	678	WP_155521503.1	hypothetical protein	-
FORC9_RS16415	374033..374674	-	642	WP_060533346.1	hypothetical protein	-
FORC9_RS23780	374799..374891	-	93	WP_080537027.1	DUF3265 domain-containing protein	-
FORC9_RS16420	374888..375139	-	252	WP_060533348.1	hypothetical protein	-
FORC9_RS16425	375379..376188	-	810	WP_060534772.1	SUMF1/EgtB/PvdO family nonheme iron enzyme	-
FORC9_RS16430	376422..376706	+	285	WP_011082348.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
FORC9_RS16435	376703..376981	+	279	WP_060533350.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FORC9_RS23785	377010..377102	-	93	WP_196374755.1	DUF3265 domain-containing protein	-
FORC9_RS16440	377422..377676	-	255	Protein_304	hypothetical protein	-
FORC9_RS16445	377686..378186	-	501	WP_038939959.1	hypothetical protein	-
FORC9_RS16450	378564..379532	+	969	WP_081036337.1	IS30 family transposase	-
FORC9_RS16455	379564..379998	-	435	WP_038939960.1	hypothetical protein	-
FORC9_RS16460	379977..380411	-	435	WP_060533352.1	hypothetical protein	-
FORC9_RS23790	380561..380653	-	93	WP_079856523.1	DUF3265 domain-containing protein	-
FORC9_RS16465	380698..381291	-	594	WP_060533354.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	370862..382861	11999
	-	flank	IS/Tn	-	-	378564..379532	968

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-45)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10975.69 Da
• Isoelectric Point: 4.3430

>T50210 WP_060533350.1 NZ_CP009985:376703-376981 [Vibrio vulnificus]
MILWEEESLNDREKIFEFLYDFNPDVPEKTDNLIEAKVENLLEQPLMGVQRDSIRGRLLIIPEISMVISYWVEGDIIRVM
RVLHQKQKFPTD

Nucleotide

• Length: 279 bp

>T50210 NZ_CP009985:376703-376981 [Vibrio vulnificus]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTCGAGTTTCTCTATGACTTCAACCCTGATGTGCC
AGAAAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGTGTACAACGAGATAGCA
TCCGCGGTCGATTACTCATTATTCCAGAGATTTCGATGGTTATCTCTTACTGGGTCGAGGGCGATATCATCCGAGTTATG
CGTGTTCTCCACCAGAAACAAAAATTCCCTACGGATTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 11083.43 Da
• Isoelectric Point: 9.2167

>AT50210 WP_011082348.1 NZ_CP009985:376422-376706 [Vibrio vulnificus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFIEHQTAKSR
MEERKARIRNRGKQ

Nucleotide

• Length: 285 bp

>AT50210 NZ_CP009985:376422-376706 [Vibrio vulnificus]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCAGAGAGTCAAGGTCGCAC
TCTTAGTGACGCATGCCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAACATTGTCTCACGATGCATGGTTAA
CTGAACAAGTAAATCTAGCATTTGAGAAGTTTGACTCAGGAAAATCCGTTTTCATTGAGCACCAAACTGCTAAATCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA

Structures

Antitoxin

• AlphaFold DB: A0A3Q0L0M2