Detailed information of TA system TA050208

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 1511893..1512442
• Replicon: chromosome
• Accession: NZ_CP009984
• Organism: Vibrio vulnificus strain FORC_009

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: FORC9_RS07025
• Protein ID: WP_060531668.1
• Coordinates: 1511893..1512192 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: FORC9_RS07030
• Protein ID: WP_039553847.1
• Coordinates: 1512200..1512442 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FORC9_RS23530	1507598..1507771	+	174	WP_081036319.1	DUF3265 domain-containing protein	-
FORC9_RS07000	1507743..1508348	+	606	WP_060531664.1	hypothetical protein	-
FORC9_RS23540	1508820..1508969	+	150	WP_081036233.1	DUF3265 domain-containing protein	-
FORC9_RS07005	1508966..1509637	+	672	WP_081036234.1	HAD-IA family hydrolase	-
FORC9_RS24195	1510135..1510302	-	168	Protein_1489	IS30 family transposase	-
FORC9_RS23545	1511739..1511831	+	93	WP_080772459.1	DUF3265 domain-containing protein	-
FORC9_RS07025	1511893..1512192	-	300	WP_060531668.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FORC9_RS07030	1512200..1512442	-	243	WP_039553847.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FORC9_RS07035	1512621..1512878	+	258	WP_005448240.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
FORC9_RS07040	1512866..1513168	+	303	WP_010448451.1	type II toxin-antitoxin system RelE/ParE family toxin	-
FORC9_RS07045	1513339..1513803	+	465	WP_060531669.1	ASCH domain-containing protein	-
FORC9_RS07050	1513837..1514805	-	969	WP_081036190.1	IS30 family transposase	-
FORC9_RS07055	1514928..1515884	-	957	WP_060531432.1	IS110 family transposase	-
FORC9_RS24210	1516119..1516178	+	60	Protein_1499	DUF3265 domain-containing protein	-
FORC9_RS23555	1516179..1516576	-	398	Protein_1500	transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1346398..1521281	174883
	-	inside	IScluster/Tn	-	-	1505354..1515884	10530
	-	inside	Integron	-	-	1472484..1513803	41319

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-52)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11401.99 Da
• Isoelectric Point: 9.6265

>T50208 WP_060531668.1 NZ_CP009984:c1512192-1511893 [Vibrio vulnificus]
MQKNKYKLSNLAQSHLRKAKNYTVENFSELQWRNYKDTLLSGFQMLADNPGLGRSCDEVYPNGFYFPIGKHTAYFTKEDG
FILVVAVLGQSQLPQNHLK

Nucleotide

• Length: 300 bp

>T50208 NZ_CP009984:c1512192-1511893 [Vibrio vulnificus]
ATGCAAAAGAACAAATACAAGCTAAGTAACTTAGCGCAATCTCACTTGCGCAAAGCAAAAAACTACACTGTTGAAAACTT
TTCTGAATTACAGTGGCGCAACTACAAAGACACTCTGCTATCAGGGTTTCAAATGCTAGCTGATAACCCTGGGTTAGGAA
GAAGCTGTGACGAGGTATACCCAAATGGCTTTTACTTCCCGATTGGAAAACACACCGCTTATTTCACTAAAGAAGATGGC
TTTATCTTAGTCGTAGCTGTCTTAGGTCAATCACAGCTCCCACAGAATCATTTGAAATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9031.26 Da
• Isoelectric Point: 5.6926

>AT50208 WP_039553847.1 NZ_CP009984:c1512442-1512200 [Vibrio vulnificus]
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDTVVVMSIRDFEELEAMKVEYLKHCFKSAKEDLNNGNAIDGESFLNSL

Nucleotide

• Length: 243 bp

>AT50208 NZ_CP009984:c1512442-1512200 [Vibrio vulnificus]
ATGCATACATTAACAGCGAATGATGCCAAACGAAATTTCGGCGAACTACTTCTAAGCGCACAACGCGAGCCGGTAAAAAT
CAGCAAAAACAGTAAAGATACTGTCGTTGTCATGTCCATTCGTGACTTTGAAGAGTTAGAAGCTATGAAAGTTGAGTACC
TCAAACACTGCTTTAAGTCAGCTAAAGAAGACTTGAACAATGGAAACGCCATTGATGGCGAAAGCTTTCTAAATTCGCTG
TAA