Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 1459176..1459714 Replicon chromosome
Accession NZ_CP009984
Organism Vibrio vulnificus strain FORC_009

Toxin (Protein)


Gene name parE Uniprot ID A0A3Q0L5T8
Locus tag FORC9_RS06690 Protein ID WP_001247271.1
Coordinates 1459176..1459475 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A0F2HR74
Locus tag FORC9_RS06695 Protein ID WP_011080384.1
Coordinates 1459472..1459714 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC9_RS06665 1454612..1455280 + 669 WP_060531578.1 hypothetical protein -
FORC9_RS23300 1455747..1455941 + 195 WP_081036218.1 DUF3265 domain-containing protein -
FORC9_RS06670 1455886..1456248 + 363 WP_011150416.1 hypothetical protein -
FORC9_RS06675 1456390..1456863 + 474 WP_064490488.1 hypothetical protein -
FORC9_RS23305 1456860..1457081 + 222 WP_081036219.1 DUF3265 domain-containing protein -
FORC9_RS06680 1457018..1457440 + 423 WP_060531582.1 VOC family protein -
FORC9_RS23310 1457450..1457578 + 129 WP_081036307.1 DUF3265 domain-containing protein -
FORC9_RS23315 1457923..1458045 + 123 WP_081036308.1 DUF3265 domain-containing protein -
FORC9_RS06685 1458063..1458578 + 516 WP_060531584.1 GNAT family N-acetyltransferase -
FORC9_RS23320 1458575..1458712 + 138 WP_081036309.1 DUF3265 domain-containing protein -
FORC9_RS23325 1459057..1459242 + 186 WP_081036220.1 DUF3265 domain-containing protein -
FORC9_RS06690 1459176..1459475 - 300 WP_001247271.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FORC9_RS06695 1459472..1459714 - 243 WP_011080384.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
FORC9_RS06700 1459941..1460360 + 420 WP_060531586.1 RDD family protein -
FORC9_RS23330 1460378..1460488 + 111 Protein_1393 DUF3265 domain-containing protein -
FORC9_RS06705 1460497..1460889 + 393 WP_060531588.1 hypothetical protein -
FORC9_RS06720 1462189..1462479 + 291 WP_060531595.1 hypothetical protein -
FORC9_RS23335 1462501..1462593 + 93 WP_081036221.1 DUF3265 domain-containing protein -
FORC9_RS06725 1462639..1463163 + 525 WP_060531596.1 AAA family ATPase -
FORC9_RS23340 1463209..1463301 + 93 WP_193288685.1 DUF3265 domain-containing protein -
FORC9_RS06730 1463341..1464009 + 669 WP_060531578.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1346398..1521281 174883
- inside Integron - - 1345144..1468980 123836


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-78)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11703.39 Da        Isoelectric Point: 9.9572

>T50205 WP_001247271.1 NZ_CP009984:c1459475-1459176 [Vibrio vulnificus]
MRPFQLTNKAKSDLRDIALFTSRRWGREQRNIYLKQFDDSFWLLAENPDIGKACDEIRDGYRKFPQGSHVIFYRQIGSQN
IEIIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T50205 NZ_CP009984:c1459475-1459176 [Vibrio vulnificus]
ATGAGACCATTTCAGTTAACTAACAAGGCGAAATCTGATTTAAGAGATATAGCCTTGTTTACCTCTCGACGTTGGGGTCG
CGAACAGCGAAATATTTATCTAAAACAGTTTGATGACTCATTTTGGCTGTTAGCCGAAAATCCTGACATTGGTAAAGCCT
GTGACGAAATTCGCGATGGCTACAGAAAGTTTCCACAAGGAAGCCACGTAATATTTTATCGTCAGATCGGCAGTCAAAAT
ATAGAGATTATCCGTATCCTCCACAAAAGCATGGATGTGAATCCAATTTTTGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8953.88 Da        Isoelectric Point: 4.2213

>AT50205 WP_011080384.1 NZ_CP009984:c1459714-1459472 [Vibrio vulnificus]
MAKNTSITLGDHFDGFIANQIQSGRYGSASEVIRSALRLLETQETKMNTLRQLLVEGEESGVADYDLDSFINELDSEERK

Download         Length: 243 bp

>AT50205 NZ_CP009984:c1459714-1459472 [Vibrio vulnificus]
ATGGCTAAGAACACTAGTATTACTTTGGGTGACCATTTTGACGGTTTTATTGCTAATCAAATCCAAAGCGGCCGCTATGG
ATCTGCAAGTGAAGTTATTCGTTCTGCTTTACGTTTACTTGAAACCCAAGAAACTAAAATGAACACTTTACGCCAGTTGC
TTGTTGAGGGCGAAGAAAGTGGAGTTGCGGATTATGACCTTGATTCGTTTATCAATGAGTTAGATAGCGAAGAGAGAAAA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Q0L5T8

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2HR74

References