Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2174088..2175063 Replicon chromosome
Accession NZ_CP009981
Organism Bacillus anthracis strain Ames isolate BACI008

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A2R2IKP2
Locus tag BF25_RS13010 Protein ID WP_002036394.1
Coordinates 2174326..2175063 (-) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag BF25_RS13005 Protein ID WP_000588712.1
Coordinates 2174088..2174213 (-) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BF25_RS12975 2169842..2170312 + 471 WP_000670597.1 DUF5065 family protein -
BF25_RS12980 2170876..2172345 - 1470 WP_000287522.1 beta-Ala-His dipeptidase -
BF25_RS31840 2172489..2172665 - 177 WP_000808045.1 hypothetical protein -
BF25_RS12990 2173004..2173240 + 237 WP_001021689.1 hypothetical protein -
BF25_RS12995 2173517..2173798 + 282 WP_001041555.1 hypothetical protein -
BF25_RS13000 2173835..2174011 - 177 WP_000852614.1 hypothetical protein -
BF25_RS13005 2174088..2174213 - 126 WP_000588712.1 hypothetical protein Antitoxin
BF25_RS13010 2174326..2175063 - 738 WP_002036394.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
BF25_RS13015 2175252..2175989 - 738 WP_000594139.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
BF25_RS13020 2176157..2176639 - 483 WP_000191911.1 MarR family winged helix-turn-helix transcriptional regulator -
BF25_RS13025 2176746..2178431 + 1686 WP_009879073.1 alpha-keto acid decarboxylase family protein -
BF25_RS13030 2178553..2179335 - 783 WP_000381787.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28373.03 Da        Isoelectric Point: 8.2705

>T50200 WP_002036394.1 NZ_CP009981:c2175063-2174326 [Bacillus anthracis]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T50200 NZ_CP009981:c2175063-2174326 [Bacillus anthracis]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTTTTTCTAGTTCTTGTTTTCTTTTACTGGAGAAATGA
AGAATTGTATGAGGAGAAGAAGCAACGAATTAGAAAGACTTGGTATGGGTTGTTTATAGTATCAGTCACCGTGTATTTCA
TGATAAAAGGAATCGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCTAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACGGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATCATTCAAAATGTCAATCCAGCAGTGTTCGGTACGATGG
AATGGCATACGGAGGAAGAATATACAAAAAGCTTAAACGCATTTTTAGATTCGTATGGGGAAAAGATTGGAGCAAAAATT
GTTGTATTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGTGGTATCCGTTCTCAATTTAGTACGATTATTCCGTTAGA
GTACATTGAGCAATTGAATGAGCAGAGAGCAGTACAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT50200 WP_000588712.1 NZ_CP009981:c2174213-2174088 [Bacillus anthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT50200 NZ_CP009981:c2174213-2174088 [Bacillus anthracis]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCGTTAATAAAAGGAGATAC
ATTACAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R2IKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References