Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 4355027..4355910 Replicon chromosome
Accession NZ_CP009974
Organism Pseudomonas putida S12

Toxin (Protein)


Gene name - Uniprot ID A0A2K4LSC9
Locus tag RPPX_RS19380 Protein ID WP_012052908.1
Coordinates 4355473..4355910 (+) Length 146 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A524BX56
Locus tag RPPX_RS19375 Protein ID WP_014591577.1
Coordinates 4355027..4355476 (+) Length 150 a.a.

Genomic Context

RPPX_RS19350RPPX_RS19370RPPX_RS19375RPPX_RS19380RPPX_RS19395RPPX_RS19355RPPX_RS19360RPPX_RS19365RPPX_RS19385RPPX_RS19390RPPX_RS19400
Location: 4350452..4351651 (1200 bp)
Type: Others
Protein ID: WP_014591581.1
Location: 4354232..4354885 (654 bp)
Type: Others
Protein ID: WP_014591578.1
Location: 4355027..4355476 (450 bp)
Type: Antitoxin
Protein ID: WP_014591577.1
Location: 4355473..4355910 (438 bp)
Type: Toxin
Protein ID: WP_012052908.1
Location: 4358383..4359612 (1230 bp)
Type: Others
Protein ID: WP_003250533.1
Location: 4351691..4352275 (585 bp)
Type: Others
Protein ID: WP_014591580.1
Location: 4352326..4353156 (831 bp)
Type: Others
Protein ID: WP_003250518.1
Location: 4353205..4354128 (924 bp)
Type: Others
Protein ID: WP_019438774.1
Location: 4355968..4357122 (1155 bp)
Type: Others
Protein ID: WP_019438775.1
Location: 4357316..4358242 (927 bp)
Type: Others
Protein ID: WP_014591574.1
Location: 4359708..4360772 (1065 bp)
Type: Others
Protein ID: WP_014591573.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
RPPX_RS193504350452..4351651+1200WP_014591581.1sugar transporter-
RPPX_RS193554351691..4352275-585WP_014591580.1LysE family transporter-
RPPX_RS193604352326..4353156-831WP_003250518.1AraC family transcriptional regulator-
RPPX_RS193654353205..4354128-924WP_019438774.1LysR family transcriptional regulator-
RPPX_RS193704354232..4354885+654WP_014591578.1oxygen-insensitive NAD(P)H-dependent nitroreductase NfsB-
RPPX_RS193754355027..4355476+450WP_014591577.1DUF2384 domain-containing proteinAntitoxin
RPPX_RS193804355473..4355910+438WP_012052908.1RES family NAD+ phosphorylaseToxin
RPPX_RS193854355968..4357122-1155WP_019438775.1aminotransferase class V-fold PLP-dependent enzyme-
RPPX_RS193904357316..4358242-927WP_014591574.1LysR family transcriptional regulator-
RPPX_RS193954358383..4359612+1230WP_003250533.1acyl-CoA dehydrogenase-
RPPX_RS194004359708..4360772-1065WP_014591573.1TerC family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-138)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(97-146)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15944.21 Da        Isoelectric Point: 5.6016

>T50198 WP_012052908.1 NZ_CP009974:4355473-4355910 [Pseudomonas putida S12]
VILWRISAYADLSGTGGLRVSGRWHQAGRPVVYAATSPPGAMLEVLVHLEIDPEDFPTTMRLLRIELPDTVSQAQLPALQ
PGWSAQPELTRTLGNRFLDDGSALLLPVPSAIMPSTTNYLFNPRHPQAQSAKIQVEDFTPDSRLF

Download         Length: 438 bp

>T50198 NZ_CP009974:4355473-4355910 [Pseudomonas putida S12]
GTGATTTTGTGGCGAATCAGCGCCTATGCAGACTTGAGCGGTACGGGGGGCTTGCGTGTAAGTGGCCGCTGGCACCAGGC
GGGTCGGCCAGTGGTGTATGCCGCCACCAGCCCTCCCGGGGCGATGCTGGAAGTGTTGGTGCACCTGGAGATCGACCCCG
AAGATTTCCCTACCACCATGCGCTTGCTGCGCATCGAACTGCCCGACACGGTTTCCCAGGCGCAGTTGCCCGCTTTGCAG
CCCGGCTGGTCTGCCCAACCTGAGTTGACCCGTACGCTGGGCAATCGCTTTCTGGATGACGGTTCGGCATTGCTGCTGCC
GGTGCCAAGCGCGATCATGCCCAGCACCACCAATTACCTGTTCAACCCACGGCACCCGCAGGCGCAGAGCGCGAAAATCC
AGGTTGAGGATTTCACCCCGGACAGCCGCCTGTTCTAG

Antitoxin


Download         Length: 150 a.a.        Molecular weight: 16984.51 Da        Isoelectric Point: 5.7258

>AT50198 WP_014591577.1 NZ_CP009974:4355027-4355476 [Pseudomonas putida S12]
MLAEVLRDNGYHEYRARLQALLDIPELASDFEIHTRITDGFAATWLVKLTERGVLTPVERDQIIPLRTLKSRIERDQPLT
VDESDRLFRSAHITAMAEAVFGEVGKAKRWLSKPKERFSGLTPMQMLTTQQGTTQVEEMLLQIAEGYGL

Download         Length: 450 bp

>AT50198 NZ_CP009974:4355027-4355476 [Pseudomonas putida S12]
ATGCTTGCCGAAGTGCTACGCGACAACGGTTACCACGAGTACCGGGCGCGCTTGCAGGCGCTGCTGGACATTCCCGAGCT
TGCCAGTGACTTCGAAATCCACACCCGCATCACCGATGGTTTTGCCGCCACCTGGTTGGTAAAGCTGACTGAACGCGGTG
TGCTCACGCCGGTGGAGCGCGACCAGATCATTCCGCTGCGCACCCTCAAATCCCGTATCGAGCGTGACCAACCGCTGACC
GTGGATGAGAGCGACCGGCTGTTCCGCTCGGCCCACATCACCGCCATGGCCGAGGCTGTGTTCGGGGAAGTGGGCAAGGC
CAAACGCTGGCTTTCCAAGCCTAAGGAACGCTTCTCGGGGCTGACGCCGATGCAGATGCTCACCACCCAGCAAGGCACCA
CGCAGGTCGAAGAAATGCTGCTGCAGATTGCCGAGGGCTATGGCCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A2K4LSC9

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A524BX56

References