Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3986431..3987051 Replicon chromosome
Accession NZ_CP009973
Organism Yersinia pestis CO92

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag AK38_RS19425 Protein ID WP_002208622.1
Coordinates 3986431..3986634 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q66DR4
Locus tag AK38_RS19430 Protein ID WP_002218472.1
Coordinates 3986683..3987051 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AK38_RS19395 3981453..3981791 + 339 WP_002208627.1 P-II family nitrogen regulator -
AK38_RS19400 3981831..3983120 + 1290 WP_002228344.1 ammonium transporter AmtB -
AK38_RS19405 3983380..3984240 - 861 WP_002208625.1 acyl-CoA thioesterase II -
AK38_RS19410 3984497..3985018 + 522 WP_002208624.1 lipoprotein -
AK38_RS19415 3985154..3985543 - 390 WP_002208623.1 MGMT family protein -
AK38_RS19425 3986431..3986634 - 204 WP_002208622.1 expression modulating protein YmoA Toxin
AK38_RS19430 3986683..3987051 - 369 WP_002218472.1 Hha toxicity modulator TomB Antitoxin
AK38_RS19435 3987210..3987563 - 354 WP_002208619.1 hypothetical protein -
AK38_RS19440 3988437..3988580 - 144 WP_002208618.1 type B 50S ribosomal protein L36 -
AK38_RS19445 3988596..3988856 - 261 WP_002208617.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T50196 WP_002208622.1 NZ_CP009973:c3986634-3986431 [Yersinia pestis CO92]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T50196 NZ_CP009973:c3986634-3986431 [Yersinia pestis CO92]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATCGATACGCTAGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGATGATGAACTGGAATTGTTTTACTCAGCTGCAGACCATCGCCTGGCTGAACTAACGATGAATAAGC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14215.00 Da        Isoelectric Point: 4.6121

>AT50196 WP_002218472.1 NZ_CP009973:c3987051-3986683 [Yersinia pestis CO92]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWINDPTSAINLQLNDLIEHIASFVMSFKIKYPDGSQLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKEHLFRLFSGEYVCTLMKT

Download         Length: 369 bp

>AT50196 NZ_CP009973:c3987051-3986683 [Yersinia pestis CO92]
ATGGATGAGTACTCGCCTAAGCGGCATGACATTGCCCAACTGAAGTTTCTATGTGAAAGCTTGTATGATGAAGGTATTGC
AACTCTTGGCGACAGCCATCATGGCTGGATAAATGACCCAACGTCGGCCATAAACCTTCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGGAAGCCAGCTTTCCGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGTAGTTATGGAATCAATGATCCTGAATTGCGTCGCTGGCAGAAAACCAAAGAGCATTT
ATTCAGACTTTTCTCAGGGGAATACGTATGTACCCTGATGAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB Q66DR4

References