Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1844913..1845585 Replicon chromosome
Accession NZ_CP009973
Organism Yersinia pestis CO92

Toxin (Protein)


Gene name cptA Uniprot ID Q666S4
Locus tag AK38_RS09530 Protein ID WP_002215144.1
Coordinates 1845160..1845585 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q666S3
Locus tag AK38_RS09525 Protein ID WP_002209939.1
Coordinates 1844913..1845179 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AK38_RS09505 1840770..1841873 + 1104 WP_002209943.1 hypothetical protein -
AK38_RS09510 1842075..1842776 + 702 WP_002209942.1 hemolysin III family protein -
AK38_RS09515 1843034..1843531 + 498 WP_002209941.1 DUF2165 family protein -
AK38_RS09520 1843604..1844596 - 993 WP_002209940.1 tRNA-modifying protein YgfZ -
AK38_RS09525 1844913..1845179 + 267 WP_002209939.1 FAD assembly factor SdhE Antitoxin
AK38_RS09530 1845160..1845585 + 426 WP_002215144.1 protein YgfX Toxin
AK38_RS09535 1845585..1846283 + 699 WP_002209937.1 two-component system response regulator CreB -
AK38_RS09540 1846308..1847726 + 1419 WP_002209936.1 two-component system sensor histidine kinase CreC -
AK38_RS09545 1847847..1849304 + 1458 WP_002220113.1 cell envelope integrity protein CreD -
AK38_RS09550 1849394..1849912 - 519 WP_002209934.1 flavodoxin FldB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16510.43 Da        Isoelectric Point: 10.3799

>T50194 WP_002215144.1 NZ_CP009973:1845160-1845585 [Yersinia pestis CO92]
VAQWRCNLRVSWHTQLFSLLAHGILVILTLVAPWPLGYTALWLVLLTLVVFECIRSQKRIKSCQGEIRLKPGNLVRWKRH
EWTVVKPPWITRYGVLLHLQQTGGHATRKRLWLSADSMSEDEWRQLCLLLRHSFESDDGTM

Download         Length: 426 bp

>T50194 NZ_CP009973:1845160-1845585 [Yersinia pestis CO92]
GTGGCCCAGTGGCGATGTAACCTGCGGGTATCCTGGCATACTCAACTCTTTTCTTTATTGGCACACGGCATATTGGTCAT
TTTAACCTTGGTCGCGCCCTGGCCCTTGGGTTATACCGCCCTATGGCTGGTATTGCTGACGTTAGTGGTGTTTGAGTGTA
TCCGCAGCCAGAAAAGGATTAAATCCTGTCAGGGGGAAATCAGGCTAAAACCTGGCAACCTGGTGCGATGGAAAAGGCAT
GAATGGACCGTGGTCAAGCCGCCGTGGATCACCCGCTATGGGGTATTATTACATTTACAACAAACAGGCGGCCACGCGAC
CCGAAAGCGTCTATGGCTGTCCGCTGACAGCATGTCTGAAGATGAGTGGCGGCAGCTATGCCTGTTGCTGCGGCATTCAT
TTGAATCTGACGATGGAACGATGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10511.98 Da        Isoelectric Point: 4.6533

>AT50194 WP_002209939.1 NZ_CP009973:1844913-1845179 [Yersinia pestis CO92]
MEIDNKARIHWACRRGMRELDISIMPFFEYEYDSLSDNEKQAFIRLLECDDPDLFNWLMNHGEPQDSELYQMVKLIQSRN
KARGPVAM

Download         Length: 267 bp

>AT50194 NZ_CP009973:1844913-1845179 [Yersinia pestis CO92]
ATGGAAATTGATAATAAAGCCCGTATTCACTGGGCATGCCGCCGTGGTATGCGTGAACTTGATATCTCCATCATGCCGTT
TTTTGAATATGAATATGATAGCTTGAGCGATAACGAGAAACAGGCATTTATCCGCTTGCTTGAGTGTGATGACCCAGATT
TATTCAACTGGCTGATGAACCACGGGGAGCCGCAGGATAGCGAGCTATATCAGATGGTCAAACTGATTCAATCACGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q666S4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XP12

References