Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-CC2985
Location 1606..2140 Replicon plasmid unnamed_1
Accession NZ_CP009972
Organism Yersinia pestis CO92

Toxin (Protein)


Gene name parE Uniprot ID Q663N8
Locus tag AK38_RS00555 Protein ID WP_002213360.1
Coordinates 1841..2140 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9ZGW3
Locus tag AK38_RS00550 Protein ID WP_002224342.1
Coordinates 1606..1848 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AK38_RS24590 504..740 + 237 WP_154020274.1 hypothetical protein -
AK38_RS24710 889..1062 - 174 WP_002213357.1 hypothetical protein -
AK38_RS23610 1148..1440 + 293 Protein_3 IS6 family transposase -
AK38_RS00550 1606..1848 + 243 WP_002224342.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
AK38_RS00555 1841..2140 + 300 WP_002213360.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AK38_RS00560 2280..2939 - 660 WP_002229754.1 type III secretion system effector GTPase activator YopE -
AK38_RS00565 3133..3525 + 393 WP_002213403.1 type III secretion system chaperone SycE/YerA -
AK38_RS00570 3588..4232 - 645 Protein_8 IS3 family transposase -
AK38_RS24020 4335..4583 + 249 Protein_9 IS21 family transposase -
AK38_RS00580 4650..5432 - 783 WP_001317493.1 IS21-like element IS100kyp family helper ATPase IstB -
AK38_RS00585 5429..6451 - 1023 WP_000255944.1 IS21-like element IS100 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - yopE / sycE/yerA / sycH / yadA / yadA / yopO/ypkA / yopJ/yopP / yopH / lcrQ/yscM / yscL / yscK / ylpB/yscJ / lcrO/yscI / yopR/yscH/lcrP / yscG / yscF / yscE / yscD / yscC / yscB / virG/yscW / yscU / yscT / yscS / yscR / yscQ / yscP / yscO / yscN / lcrE/yopN / tyeA / sycN / yscX / yscY / yscV/lcrD / lcrR / lcrG / lcrV / sycD/lcrH / yopB / yopD / yopM / sycT / yopT / yopK/yopQ 1..70305 70305


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

Antitoxin ParD

(5-72)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11632.19 Da        Isoelectric Point: 5.5114

>T50183 WP_002213360.1 NZ_CP009972:1841-2140 [Yersinia pestis CO92]
VYKLSELADEDIYNIASYTIRHFGVTQAKLYHENLAKVFELLAKNPELGAECNWICSDIRRFQYKKHGIYYITLSNDILI
SRVLHQSIDIDVQDFPEHE

Download         Length: 300 bp

>T50183 NZ_CP009972:1841-2140 [Yersinia pestis CO92]
GTGTATAAACTGTCTGAACTAGCTGATGAGGATATTTATAATATTGCCAGTTATACTATCCGGCATTTCGGTGTGACTCA
GGCTAAGTTATACCATGAGAACTTGGCAAAGGTATTCGAGCTATTAGCTAAAAATCCAGAGTTAGGGGCTGAGTGTAACT
GGATTTGCTCTGATATTCGCCGTTTTCAGTATAAAAAGCACGGTATATACTATATAACGCTTAGCAATGATATTTTGATT
TCTCGAGTGCTGCATCAATCCATAGATATAGATGTTCAGGATTTTCCAGAGCATGAGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8865.15 Da        Isoelectric Point: 6.4781

>AT50183 WP_002224342.1 NZ_CP009972:1606-1848 [Yersinia pestis CO92]
MAHVTSVTLGEHLTGFVGEMIQSGRYGNISEVLRDALRLMEAREQRVQHVRDMVLAGTNVPVSHRLMDEIFSAAVKDTSV

Download         Length: 243 bp

>AT50183 NZ_CP009972:1606-1848 [Yersinia pestis CO92]
ATGGCTCACGTAACCAGCGTAACACTTGGAGAGCATTTGACAGGTTTTGTGGGGGAAATGATTCAGTCTGGTCGTTATGG
CAATATATCAGAAGTGCTTCGTGATGCCTTAAGGCTAATGGAAGCACGTGAACAGCGTGTTCAACATGTACGCGATATGG
TGCTTGCAGGAACAAATGTACCTGTGAGCCATCGTTTAATGGATGAGATTTTTTCTGCTGCGGTGAAAGATACTAGTGTA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q663N8

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1NQY6

References