Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 3095886..3096861 Replicon chromosome
Accession NZ_CP009968
Organism Bacillus cereus E33L

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A7U6C7L7
Locus tag BF28_RS18865 Protein ID WP_002021399.1
Coordinates 3096124..3096861 (-) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A1J9W3Q2
Locus tag BF28_RS18860 Protein ID WP_000594606.1
Coordinates 3095886..3096011 (-) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BF28_RS18830 3091630..3092100 + 471 WP_000771838.1 DUF5065 family protein -
BF28_RS18835 3092681..3094150 - 1470 WP_000287519.1 beta-Ala-His dipeptidase -
BF28_RS33125 3094294..3094470 - 177 WP_000808045.1 hypothetical protein -
BF28_RS18845 3094802..3095038 + 237 WP_001021691.1 hypothetical protein -
BF28_RS18850 3095315..3095590 + 276 WP_001041552.1 hypothetical protein -
BF28_RS33130 3095634..3095810 - 177 WP_000852613.1 hypothetical protein -
BF28_RS18860 3095886..3096011 - 126 WP_000594606.1 hypothetical protein Antitoxin
BF28_RS18865 3096124..3096861 - 738 WP_002021399.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
BF28_RS18870 3097050..3097787 - 738 WP_000594155.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
BF28_RS18875 3097955..3098437 - 483 WP_000191911.1 MarR family winged helix-turn-helix transcriptional regulator -
BF28_RS18880 3098544..3100229 + 1686 WP_011198735.1 alpha-keto acid decarboxylase family protein -
BF28_RS33135 3100351..3100443 - 93 Protein_3156 methyltransferase -
BF28_RS18885 3100549..3100956 - 408 WP_000072487.1 VOC family protein -
BF28_RS18890 3101076..3101786 - 711 WP_000787479.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28331.03 Da        Isoelectric Point: 8.2638

>T50181 WP_002021399.1 NZ_CP009968:c3096861-3096124 [Bacillus cereus E33L]
VISNIRIGLFILAIVFLVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T50181 NZ_CP009968:c3096861-3096124 [Bacillus cereus E33L]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTTTTTCTAGTACTTGTTTTCTTTTATTGGAAAAACGA
AGAGTTGTACGAGGAGAAGAAGCAACGTATTAGAAAGACTTGGTATGGGTTGTTTATAATATCAGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCTAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACAGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATCATTCAAAATGTCAATCCAGCAGTGTTCGGTACGATGG
AATGGCATACGGAGGAAGAATATACAAAAAGCTTAAACGCATTTTTAGATTCGTATGGGGAAAAGATTGGAGCAAAAATT
GTTGTATTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGCGGTATCCGTTCTCAATTTAGTACGATTATTCCATTAGA
GTACATTGAGCAATTGAATGAGCAGAAAGCAGTACAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4860.23 Da        Isoelectric Point: 3.9507

>AT50181 WP_000594606.1 NZ_CP009968:c3096011-3095886 [Bacillus cereus E33L]
VIKNNDNDFFKEDNEDTTDFSLIKGDTLQQVEDLEDELKRK

Download         Length: 126 bp

>AT50181 NZ_CP009968:c3096011-3095886 [Bacillus cereus E33L]
GTGATAAAAAATAATGATAATGATTTTTTTAAAGAAGACAATGAAGATACAACGGATTTCTCGTTAATAAAAGGAGATAC
ATTACAGCAAGTAGAAGATTTAGAAGATGAATTAAAAAGAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U6C7L7

Antitoxin

Source ID Structure
AlphaFold DB A0A1J9W3Q2

References