Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 614330..616066 Replicon chromosome
Accession NZ_CP009962
Organism Collimonas arenae strain Cal35

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag LT85_RS02670 Protein ID WP_038484911.1
Coordinates 614330..615214 (+) Length 295 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A0A1F7C4
Locus tag LT85_RS02675 Protein ID WP_038484914.1
Coordinates 615224..616066 (+) Length 281 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LT85_RS02650 610349..611308 + 960 WP_038484900.1 NAD(P)-dependent oxidoreductase -
LT85_RS02655 611377..612669 + 1293 WP_038484902.1 MFS transporter -
LT85_RS02660 612957..613721 + 765 WP_038484905.1 SDR family oxidoreductase -
LT85_RS02665 613769..614308 + 540 WP_038484908.1 cupin domain-containing protein -
LT85_RS02670 614330..615214 + 885 WP_038484911.1 alpha/beta hydrolase Toxin
LT85_RS02675 615224..616066 + 843 WP_038484914.1 IclR family transcriptional regulator Antitoxin
LT85_RS02680 616072..616881 + 810 WP_038484917.1 SDR family oxidoreductase -
LT85_RS02685 616874..618571 + 1698 WP_038484920.1 thiamine pyrophosphate-binding protein -
LT85_RS02690 618582..619388 + 807 WP_038484923.1 aspartate dehydrogenase -
LT85_RS02695 619404..620879 + 1476 WP_038484927.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-284)

Antitoxin

Transcription regulator IclR, N-terminal

(22-71)


Sequences

Toxin        


Download         Length: 295 a.a.        Molecular weight: 31164.61 Da        Isoelectric Point: 6.9919

>T50180 WP_038484911.1 NZ_CP009962:614330-615214 [Collimonas arenae]
MSTATATACATQLEHALGLMARGFSERTVDVGGSLVSYRSCGTAVPGGKTVVLLHGIGSGAASWLQCALDLQQDAQVVAW
NAPGYGGSSALPMARPSAADYAMRLEQLLQALDVRNCVLVGHSLGALMASAYVAAGYTRAEQLLLVSPAQGYGGGDKRVR
GEEIAQQRLAALENLGIAGMALKSPERMLSVQASEFARAWVRWNTQRLNPASYTQAVYMLCGDDIHRYRLPAAGPACAIY
CGADDVVTTPQDSRMLADSLRLPFQLIEAAGHACYIEQPQAVAAVIRRHLDQLS

Download         Length: 885 bp

>T50180 NZ_CP009962:614330-615214 [Collimonas arenae]
ATGTCGACCGCCACCGCCACCGCCTGCGCCACGCAACTGGAACACGCCCTGGGCCTGATGGCGCGGGGGTTTTCCGAGCG
CACTGTCGATGTTGGCGGCAGCCTGGTTTCCTATCGTAGCTGCGGCACAGCGGTGCCCGGCGGCAAAACGGTAGTCCTGT
TGCATGGCATCGGTTCGGGCGCTGCATCCTGGCTACAGTGCGCCTTGGATTTGCAACAGGATGCACAGGTCGTCGCCTGG
AATGCGCCCGGCTACGGCGGCTCATCGGCATTGCCGATGGCGCGTCCCAGCGCAGCAGATTACGCCATGCGCCTGGAGCA
GCTTCTGCAAGCGTTGGATGTGCGCAATTGCGTATTGGTTGGGCATTCGCTGGGTGCGTTGATGGCATCCGCATATGTCG
CCGCGGGTTACACCCGCGCCGAGCAACTATTGCTGGTCAGTCCGGCGCAGGGTTATGGCGGCGGTGACAAGCGCGTGCGT
GGCGAAGAGATTGCGCAGCAACGTCTGGCGGCACTGGAAAACCTGGGTATCGCGGGGATGGCCCTGAAAAGCCCGGAGCG
GATGCTGTCGGTGCAAGCCAGCGAATTCGCCCGCGCCTGGGTGCGCTGGAATACGCAAAGGCTGAATCCCGCCAGTTACA
CGCAAGCGGTATACATGCTGTGCGGCGACGATATCCACCGCTACCGATTACCCGCAGCAGGGCCGGCGTGTGCGATATAT
TGCGGCGCTGACGACGTGGTTACCACGCCGCAGGACAGCCGGATGCTGGCCGATAGTTTGCGGTTGCCGTTCCAGCTGAT
AGAAGCTGCTGGACATGCCTGCTACATCGAACAGCCGCAAGCAGTCGCTGCAGTGATACGTCGTCATCTTGATCAACTCT
CTTAA

Antitoxin


Download         Length: 281 a.a.        Molecular weight: 31221.71 Da        Isoelectric Point: 5.4749

>AT50180 WP_038484914.1 NZ_CP009962:615224-616066 [Collimonas arenae]
MNKIELPEEENQEQEKYLVPGLERGLRLLCEFSRQDKSLSAPELARRLSVPRSTVFRLLTTLERMGFVERNEGGRDYRLG
MAVLRLGFEYLASLELTEIGRPLLDRLRDQISYPCNLVVRDGRSIVYVAKSVTPTAFVSSVNVGTRLPAHATVLGRVLLE
DLSLAELRELYPEEHLESFSSNTPKTVVELFDMVQQDKARGYVLQEGFFETGISTIAAPVRDHSGKVVAAMGATIPLPHI
DASQLDGIVRSVRDTAGELSGLLDHAPEKSGSKVVNMWRE

Download         Length: 843 bp

>AT50180 NZ_CP009962:615224-616066 [Collimonas arenae]
ATGAATAAAATAGAGCTGCCAGAAGAAGAAAACCAAGAGCAAGAAAAATATCTCGTGCCGGGGCTGGAGCGCGGTTTGCG
CCTGTTGTGTGAATTCAGCCGTCAGGACAAGAGTCTGTCGGCGCCGGAACTGGCGCGCCGCTTGAGTGTGCCGCGTTCGA
CCGTGTTTCGCCTGCTGACCACGCTGGAACGCATGGGCTTTGTCGAACGCAACGAAGGTGGCCGCGATTACCGCCTTGGC
ATGGCAGTGCTGCGCCTCGGTTTTGAATACCTGGCTTCGCTGGAACTGACGGAAATCGGCCGGCCGTTGCTGGACCGCCT
GCGTGACCAGATTTCATATCCCTGCAACCTTGTGGTGCGCGACGGCCGCTCCATTGTATATGTCGCCAAATCGGTGACGC
CGACCGCATTCGTCAGTTCGGTCAATGTCGGTACACGTTTGCCGGCGCACGCCACGGTCCTCGGCCGCGTGCTGCTGGAA
GATCTGTCGCTGGCCGAGTTGCGTGAACTGTATCCGGAAGAACATCTGGAAAGCTTCTCCAGCAATACGCCGAAGACCGT
CGTAGAACTGTTCGACATGGTGCAGCAGGATAAAGCGCGCGGTTATGTGCTGCAGGAAGGTTTTTTCGAAACCGGCATCT
CGACCATCGCCGCACCGGTGCGCGATCACTCTGGCAAGGTAGTTGCGGCGATGGGAGCGACGATTCCTTTGCCGCATATC
GATGCGAGCCAACTCGATGGCATCGTACGGAGCGTGCGCGATACCGCCGGCGAGTTATCGGGTTTGCTGGACCACGCCCC
TGAGAAATCAGGCAGCAAGGTCGTCAACATGTGGCGGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0A1F7C4

References