Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 202229..202880 Replicon chromosome
Accession NZ_CP009962
Organism Collimonas arenae strain Cal35

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LT85_RS00915 Protein ID WP_038484181.1
Coordinates 202229..202405 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LT85_RS00920 Protein ID WP_038484184.1
Coordinates 202464..202880 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LT85_RS00890 197665..197880 - 216 WP_172656926.1 helix-turn-helix transcriptional regulator -
LT85_RS00895 198439..199470 - 1032 WP_038484168.1 NAD-binding protein -
LT85_RS00900 199923..200225 + 303 WP_038484171.1 type II toxin-antitoxin system HigB family toxin -
LT85_RS00905 200222..200647 + 426 WP_038484175.1 helix-turn-helix domain-containing protein -
LT85_RS00910 200655..201914 - 1260 WP_038484178.1 DEAD/DEAH box helicase -
LT85_RS00915 202229..202405 + 177 WP_038484181.1 type II toxin-antitoxin system HicA family toxin Toxin
LT85_RS00920 202464..202880 + 417 WP_038484184.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LT85_RS00925 203028..205499 - 2472 WP_038484187.1 DEAD/DEAH box helicase -
LT85_RS00930 205496..206269 - 774 WP_038484189.1 fumarylacetoacetate hydrolase family protein -
LT85_RS00935 206273..207025 - 753 WP_038484192.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-57)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6606.74 Da        Isoelectric Point: 11.2962

>T50179 WP_038484181.1 NZ_CP009962:202229-202405 [Collimonas arenae]
MKQSEFVKWLRQQGATFVEGANHTKVTLKGRTSFLPRHPSKELKTGLVEGVKKQLNLK

Download         Length: 177 bp

>T50179 NZ_CP009962:202229-202405 [Collimonas arenae]
ATGAAGCAGAGCGAATTTGTTAAGTGGCTCAGACAGCAAGGAGCGACTTTCGTAGAGGGGGCGAACCATACCAAAGTGAC
CCTGAAAGGCAGGACAAGCTTCTTGCCCCGACATCCCTCCAAGGAACTTAAAACAGGACTTGTCGAAGGCGTAAAAAAAC
AACTCAATCTAAAGTGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15230.66 Da        Isoelectric Point: 4.9746

>AT50179 WP_038484184.1 NZ_CP009962:202464-202880 [Collimonas arenae]
MKYPAVFSADQDGGFVVTFRDIPEAITQGDDETEAMAMARDVLLEAMRVYFDEKRTVPSPSKARPGERLVDLPLSARAKI
LLLNEMLAKKIGPSALARMMDTTPQEINRLIDLNHTTKIDRIGDAMSALGKQLELIAA

Download         Length: 417 bp

>AT50179 NZ_CP009962:202464-202880 [Collimonas arenae]
ATGAAATACCCTGCAGTCTTTAGCGCCGACCAGGATGGCGGCTTTGTGGTGACGTTTCGTGACATTCCTGAAGCGATCAC
GCAAGGTGACGATGAAACGGAAGCCATGGCAATGGCGCGCGACGTACTGCTCGAAGCAATGCGCGTTTACTTCGATGAAA
AACGTACGGTGCCATCGCCGTCGAAAGCGCGGCCTGGCGAGCGCCTGGTGGATCTGCCTCTCAGCGCCCGCGCAAAAATA
CTATTGCTGAACGAGATGCTTGCAAAAAAGATCGGCCCCTCTGCCCTGGCGCGGATGATGGACACCACGCCGCAGGAAAT
CAATCGCCTGATAGATCTCAACCACACCACGAAGATTGACCGCATCGGAGATGCGATGAGCGCGCTGGGTAAGCAACTTG
AGCTGATTGCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References