Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4199622..4200242 Replicon chromosome
Accession NZ_CP009935
Organism Yersinia pestis Angola

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag CH56_RS20405 Protein ID WP_002208622.1
Coordinates 4200039..4200242 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q66DR4
Locus tag CH56_RS20400 Protein ID WP_002218472.1
Coordinates 4199622..4199990 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH56_RS20370 4196241..4196903 + 663 WP_002228565.1 hypothetical protein -
CH56_RS20380 4197121..4197579 + 459 WP_002213775.1 IS200/IS605-like element IS1541B family transposase -
CH56_RS20385 4197817..4198077 + 261 Protein_3705 type B 50S ribosomal protein L31 -
CH56_RS20390 4198093..4198236 + 144 WP_002208618.1 type B 50S ribosomal protein L36 -
CH56_RS20395 4199110..4199463 + 354 WP_002208619.1 hypothetical protein -
CH56_RS20400 4199622..4199990 + 369 WP_002218472.1 Hha toxicity modulator TomB Antitoxin
CH56_RS20405 4200039..4200242 + 204 WP_002208622.1 expression modulating protein YmoA Toxin
CH56_RS20410 4201130..4201519 + 390 WP_002208623.1 MGMT family protein -
CH56_RS20415 4201629..4202117 - 489 Protein_3711 YbaY family lipoprotein -
CH56_RS20420 4202374..4203234 + 861 WP_002208625.1 acyl-CoA thioesterase II -
CH56_RS20425 4203494..4204783 - 1290 WP_002228344.1 ammonium transporter AmtB -
CH56_RS20430 4204823..4205161 - 339 WP_002208627.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4197121..4197579 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T50171 WP_002208622.1 NZ_CP009935:4200039-4200242 [Yersinia pestis Angola]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T50171 NZ_CP009935:4200039-4200242 [Yersinia pestis Angola]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATCGATACGCTAGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGATGATGAACTGGAATTGTTTTACTCAGCTGCAGACCATCGCCTGGCTGAACTAACGATGAATAAGC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14215.00 Da        Isoelectric Point: 4.6121

>AT50171 WP_002218472.1 NZ_CP009935:4199622-4199990 [Yersinia pestis Angola]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWINDPTSAINLQLNDLIEHIASFVMSFKIKYPDGSQLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKEHLFRLFSGEYVCTLMKT

Download         Length: 369 bp

>AT50171 NZ_CP009935:4199622-4199990 [Yersinia pestis Angola]
ATGGATGAGTACTCGCCTAAGCGGCATGACATTGCCCAACTGAAGTTTCTATGTGAAAGCTTGTATGATGAAGGTATTGC
AACTCTTGGCGACAGCCATCATGGCTGGATAAATGACCCAACGTCGGCCATAAACCTTCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGGAAGCCAGCTTTCCGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGTAGTTATGGAATCAATGATCCTGAATTGCGTCGCTGGCAGAAAACCAAAGAGCATTT
ATTCAGACTTTTCTCAGGGGAATACGTATGTACACTGATGAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB Q66DR4

References