Detailed information of TA system TA050170

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /COG5642-COG5654
• Location: 3644172..3645155
• Replicon: chromosome
• Accession: NZ_CP009935
• Organism: Yersinia pestis Angola

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A0E8XJV6
• Locus tag: CH56_RS17850
• Protein ID: WP_002210981.1
• Coordinates: 3644697..3645155 (+)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: CH56_RS17845
• Protein ID: WP_012229742.1
• Coordinates: 3644172..3644618 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CH56_RS17825	3639604..3640383	-	780	WP_001297096.1	IS21-like element IS100kyp family helper ATPase IstB	-
CH56_RS17830	3640383..3641405	-	1023	WP_042666698.1	IS21-like element IS100 family transposase	-
CH56_RS17835	3641655..3642112	+	458	Protein_3227	IS200/IS605-like element IS1541B family transposase	-
CH56_RS17840	3642259..3643836	-	1578	WP_002210983.1	transcriptional regulator TyrR	-
CH56_RS17845	3644172..3644618	+	447	WP_012229742.1	DUF2384 domain-containing protein	Antitoxin
CH56_RS17850	3644697..3645155	+	459	WP_002210981.1	RES family NAD+ phosphorylase	Toxin
CH56_RS17855	3645165..3646226	-	1062	WP_002210980.1	YcjF family protein	-
CH56_RS17860	3646223..3647620	-	1398	WP_002210979.1	YcjX family protein	-
CH56_RS17865	3647601..3647843	-	243	WP_002216375.1	phage shock protein PspD	-
CH56_RS17870	3647928..3648287	-	360	WP_002210977.1	envelope stress response membrane protein PspC	-
CH56_RS17875	3648287..3648514	-	228	WP_002210976.1	envelope stress response membrane protein PspB	-
CH56_RS17880	3648676..3649341	-	666	WP_002210975.1	phage shock protein PspA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (2-147)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (36-90)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 16994.38 Da
• Isoelectric Point: 4.8732

>T50170 WP_002210981.1 NZ_CP009935:3644697-3645155 [Yersinia pestis Angola]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSVGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Nucleotide

• Length: 459 bp

>T50170 NZ_CP009935:3644697-3645155 [Yersinia pestis Angola]
ATGACGCTATACCGCATTGTTATGCGCCGCTATCTTGCATCGGCATGGACTGGTTACGGCGCTGAAATCTATGGTGGTCG
TTGGAATCATAAAGGCCATGCTGCCATCTATTTAGCCAGCAGTATTTCATTGGCTATGCTCGAAACACTGGCACATATTC
AGGACAGTTCAACACTCAGCGAATTTGAATTATTCCAAATTGAAATCAGTGACAGCAGTATTATGTTGCTACAGCCGCAG
GACTGGCCCACGGATTGGCGTAGCGATCCGGCACCGGTGGCAACGATGGATGTCGGCACCGAGTGGCTGGAATCAGAATC
CTCGGTAGGCTTACTGGTCCCGTCCACGTTGGTGCCGTCAGAAAACAACCTACTGGTCAATCCTCATCACAAAGATTTTC
CAGCGTGTTTGGCCAGCGTCAAACCGCTCTCTTTTGTCTTTGATCCACGGTTAAAATAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16389.89 Da
• Isoelectric Point: 9.7155

>AT50170 WP_012229742.1 NZ_CP009935:3644172-3644618 [Yersinia pestis Angola]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKATTWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Nucleotide

• Length: 447 bp

>AT50170 NZ_CP009935:3644172-3644618 [Yersinia pestis Angola]
ATGAGAGCGTACCGCCCAAACCCCGCGACTAAAATGGGAACGCTTTGGCGTGAAATTGGCTTACCCGCCAGCCGCGGCAC
GATATTGGTCGATAGTATCAAAATGGGGTTTTCTGTTGATGTTATCGACAGCATTCATTTATGGGCATCCATGCCTAAAG
CTGAAATATTACGTGCTACCGGTATCCCCAGCCGTAGCCTGACTCGCCGCCGCACACATGATGGCCGTTTTACGCCTGAA
GAAAGCGAGAGAATCGCACGTTTTGTCCGCGTAATGGATGCCGCTGTCGATTTGTTCGGCGGCGATAAAGGTAAAGCCAC
TACCTGGATGTCCACGCCCATCAAAGGATTGGGGTACCGCAGCCCAGACTCCTTACTGGAAACCGAAACTGGCGCACTGG
AAGTGTGTGATTTGATTGGTCGTTTGGAACACGGCGTCTTTACTTAA

Structures

Toxin

• AlphaFold DB: A0A0E8XJV6