Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 570923..571595 Replicon chromosome
Accession NZ_CP009935
Organism Yersinia pestis Angola

Toxin (Protein)


Gene name cptA Uniprot ID Q666S4
Locus tag CH56_RS03290 Protein ID WP_002215144.1
Coordinates 571170..571595 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q666S3
Locus tag CH56_RS03285 Protein ID WP_002209939.1
Coordinates 570923..571189 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH56_RS03265 566779..567883 + 1105 Protein_507 hypothetical protein -
CH56_RS03270 568085..568786 + 702 WP_002209942.1 hemolysin III family protein -
CH56_RS03275 569044..569541 + 498 WP_002209941.1 DUF2165 family protein -
CH56_RS03280 569614..570606 - 993 WP_002209940.1 tRNA-modifying protein YgfZ -
CH56_RS03285 570923..571189 + 267 WP_002209939.1 FAD assembly factor SdhE Antitoxin
CH56_RS03290 571170..571595 + 426 WP_002215144.1 protein YgfX Toxin
CH56_RS03295 571595..572293 + 699 WP_012230137.1 two-component system response regulator CreB -
CH56_RS03300 572304..573722 + 1419 WP_002209936.1 two-component system sensor histidine kinase CreC -
CH56_RS03305 573822..575279 + 1458 WP_002220113.1 cell envelope integrity protein CreD -
CH56_RS03310 575369..575887 - 519 WP_002209934.1 flavodoxin FldB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 402952..574263 171311


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16510.43 Da        Isoelectric Point: 10.3799

>T50160 WP_002215144.1 NZ_CP009935:571170-571595 [Yersinia pestis Angola]
VAQWRCNLRVSWHTQLFSLLAHGILVILTLVAPWPLGYTALWLVLLTLVVFECIRSQKRIKSCQGEIRLKPGNLVRWKRH
EWTVVKPPWITRYGVLLHLQQTGGHATRKRLWLSADSMSEDEWRQLCLLLRHSFESDDGTM

Download         Length: 426 bp

>T50160 NZ_CP009935:571170-571595 [Yersinia pestis Angola]
GTGGCCCAGTGGCGATGTAACCTGCGGGTATCCTGGCATACTCAACTCTTTTCTTTATTGGCACACGGCATATTGGTCAT
TTTAACCTTGGTCGCGCCCTGGCCCTTGGGTTATACCGCCCTATGGCTGGTATTGCTGACGTTAGTGGTGTTTGAGTGTA
TCCGCAGCCAGAAAAGGATTAAATCCTGTCAGGGGGAAATCAGGCTAAAACCTGGCAACCTGGTGCGATGGAAAAGGCAT
GAATGGACCGTGGTCAAGCCGCCGTGGATCACCCGCTATGGGGTATTATTACATTTACAACAAACAGGCGGCCACGCGAC
CCGAAAGCGTCTATGGCTGTCCGCTGACAGCATGTCTGAAGATGAGTGGCGGCAGCTATGCCTGTTGCTGCGGCATTCAT
TTGAATCTGACGATGGAACGATGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10511.98 Da        Isoelectric Point: 4.6533

>AT50160 WP_002209939.1 NZ_CP009935:570923-571189 [Yersinia pestis Angola]
MEIDNKARIHWACRRGMRELDISIMPFFEYEYDSLSDNEKQAFIRLLECDDPDLFNWLMNHGEPQDSELYQMVKLIQSRN
KARGPVAM

Download         Length: 267 bp

>AT50160 NZ_CP009935:570923-571189 [Yersinia pestis Angola]
ATGGAAATTGATAATAAAGCCCGTATTCACTGGGCATGCCGCCGTGGTATGCGTGAACTTGATATCTCCATCATGCCGTT
TTTTGAATATGAATATGATAGCTTGAGCGATAACGAGAAACAGGCATTTATCCGCTTGCTTGAGTGTGATGACCCAGATT
TATTCAACTGGCTGATGAACCACGGGGAGCCGCAGGATAGCGAGCTATATCAGATGGTCAAACTGATTCAATCACGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q666S4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XP12

References