Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 2788267..2788922 Replicon chromosome
Accession NZ_CP009929
Organism Burkholderia mallei strain FMH

Toxin (Protein)


Gene name relE Uniprot ID A0A0H2WL39
Locus tag RY28_RS14620 Protein ID WP_004199884.1
Coordinates 2788267..2788563 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q63YL3
Locus tag RY28_RS14625 Protein ID WP_004202809.1
Coordinates 2788566..2788922 (+) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RY28_RS14595 2783793..2784221 + 429 WP_004199881.1 helix-turn-helix domain-containing protein -
RY28_RS14600 2784541..2785323 - 783 WP_004201278.1 flagellar biosynthetic protein FliR -
RY28_RS14605 2785442..2785714 - 273 WP_004199882.1 flagellar biosynthesis protein FliQ -
RY28_RS14610 2785740..2786291 - 552 Protein_2454 flagellar type III secretion system pore protein FliP -
RY28_RS14620 2788267..2788563 + 297 WP_004199884.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
RY28_RS14625 2788566..2788922 + 357 WP_004202809.1 putative addiction module antidote protein Antitoxin
RY28_RS14630 2788966..2790021 - 1056 WP_004199886.1 phage portal protein -
RY28_RS14635 2790018..2790515 - 498 WP_004199888.1 terminase -
RY28_RS14645 2790737..2791258 - 522 WP_004199890.1 ClpXP protease specificity-enhancing factor -
RY28_RS14650 2791328..2791939 - 612 WP_004185176.1 glutathione S-transferase N-terminal domain-containing protein -
RY28_RS14655 2792032..2792790 - 759 WP_004199892.1 cytochrome c1 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - fliR / fliQ / fliP 2779394..2790332 10938


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(8-97)

Antitoxin

Uncharacterized protein HI1420

(16-94)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10840.66 Da        Isoelectric Point: 10.1723

>T50154 WP_004199884.1 NZ_CP009929:2788267-2788563 [Burkholderia mallei]
MFKVLTPPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFVRRGKIIVVVLCGGDKS
TQKKDIKLAKQIAGELED

Download         Length: 297 bp

>T50154 NZ_CP009929:2788267-2788563 [Burkholderia mallei]
ATGTTCAAAGTTCTGACGCCCCCCCAGTTTGACAAATGGCTTGACGGGCTTCGCGATCCGGTCGGTAGCGCGGCAATCAA
CCTGCGCATCGAGCGGGCGAAGCTTGGCAATCTCGGCCAGTGGCGCGCAGTCGGCGACGGCGTCAACGAAATGAAGATTG
ATGTGGGGCCGGGATATCGGGCCTATTTCGTGCGGCGCGGAAAAATTATCGTCGTGGTGTTGTGCGGCGGGGACAAGTCG
ACGCAGAAGAAGGACATCAAGCTAGCGAAGCAAATCGCTGGCGAACTGGAGGATTGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 12585.41 Da        Isoelectric Point: 9.9470

>AT50154 WP_004202809.1 NZ_CP009929:2788566-2788922 [Burkholderia mallei]
MKISELAEFDGSKYLKDEETIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVGALGLHLTVAPAEPAPVPAPATTRARSRVRTAAHA

Download         Length: 357 bp

>AT50154 NZ_CP009929:2788566-2788922 [Burkholderia mallei]
ATGAAAATCAGCGAACTGGCCGAGTTCGACGGCTCGAAGTACCTGAAGGACGAGGAAACGATTCGTCACTACCTGGCGCA
AGCGTTCGAGGATGGAAACCCGCGGCTGATTCAAGCCGCGCTCGGAAACGTCGCGAAAGCGCGCGGCATGACAGCGCTCG
CGCGCGAGTCCGGCGTGAAGCGTGAAGCGCTCTATCGCGCGCTGTCGGAAGGTGGGAACGCGGAATTCGCAACGATCATG
AAAGTTGTGGGCGCGTTGGGGCTGCACCTGACCGTTGCGCCGGCCGAACCTGCGCCGGTGCCCGCGCCGGCAACAACGCG
TGCACGCTCGCGCGTTCGCACGGCTGCGCACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2WL39

Antitoxin

Source ID Structure
AlphaFold DB A0A3N4G1D3

References