Detailed information of TA system TA050153

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-YefM
• Location: 2710772..2711301
• Replicon: chromosome
• Accession: NZ_CP009922
• Organism: Streptomyces xiamenensis strain MCCC 1A01550

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A0F7FTZ9
• Locus tag: SXIM_RS12400
• Protein ID: WP_046723985.1
• Coordinates: 2710772..2711029 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: SXIM_RS12405
• Protein ID: WP_046723986.1
• Coordinates: 2711026..2711301 (-)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SXIM_RS12370	2706277..2706996	-	720	WP_030735523.1	DUF5063 domain-containing protein	-
SXIM_RS12375	2707030..2707629	-	600	WP_030735527.1	recombination mediator RecR	-
SXIM_RS12380	2707718..2708062	-	345	WP_078635678.1	YbaB/EbfC family nucleoid-associated protein	-
SXIM_RS12385	2708143..2710224	-	2082	WP_046723983.1	DNA polymerase III subunit gamma and tau	-
SXIM_RS12400	2710772..2711029	-	258	WP_046723985.1	Txe/YoeB family addiction module toxin	Toxin
SXIM_RS12405	2711026..2711301	-	276	WP_046723986.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
SXIM_RS12410	2711809..2712012	+	204	WP_046723987.1	type II toxin-antitoxin system VapB family antitoxin	-
SXIM_RS12415	2712009..2712432	+	424	Protein_2437	PIN domain nuclease	-
SXIM_RS12420	2712615..2712854	+	240	WP_148236105.1	hypothetical protein	-
SXIM_RS12425	2712869..2714311	-	1443	WP_046723989.1	DUF2236 domain-containing protein	-
SXIM_RS12430	2714308..2715057	-	750	WP_168222765.1	di-trans,poly-cis-decaprenylcistransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (6-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-72)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10257.72 Da
• Isoelectric Point: 10.3066

>T50153 WP_046723985.1 NZ_CP009922:c2711029-2710772 [Streptomyces xiamenensis]
VRNVNFDPAAWDDFLFWLASDRKTARRITRLIAEIQRTPFEGIGKPEPLKGDLTGYWSRRINDEHRLVYRTDDKEMKIIK
ARYRY

Nucleotide

• Length: 258 bp

>T50153 NZ_CP009922:c2711029-2710772 [Streptomyces xiamenensis]
GTGAGGAACGTCAACTTCGACCCGGCCGCCTGGGACGACTTTCTGTTCTGGCTCGCGTCGGACAGGAAGACGGCCCGGCG
GATCACTCGTCTCATCGCCGAGATCCAACGCACCCCCTTCGAGGGCATCGGCAAACCGGAGCCGCTGAAGGGTGACCTCA
CGGGTTACTGGTCGCGGCGGATCAATGACGAACACCGGCTCGTCTACCGCACCGATGACAAGGAAATGAAGATCATCAAG
GCCCGCTACCGCTACTGA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10054.20 Da
• Isoelectric Point: 4.3217

>AT50153 WP_046723986.1 NZ_CP009922:c2711301-2711026 [Streptomyces xiamenensis]
MSISASEARKSLFPLIERVNTDHDPVRITSKAGDAVLMSADDYDSWQETIYLLRSPANAQRLMEAVARDKAGEAEVARTL
DELRDMAGGEE

Nucleotide

• Length: 276 bp

>AT50153 NZ_CP009922:c2711301-2711026 [Streptomyces xiamenensis]
ATGAGTATCAGTGCCAGTGAAGCCAGAAAAAGCCTGTTCCCGCTCATCGAACGTGTGAACACCGACCACGACCCGGTGCG
GATCACGTCCAAGGCCGGGGACGCCGTCCTGATGTCCGCCGATGACTACGACTCCTGGCAGGAGACCATCTACCTTCTGC
GTTCCCCCGCCAATGCCCAGCGGCTCATGGAGGCGGTAGCCCGGGACAAAGCGGGCGAGGCCGAAGTCGCCAGGACGCTC
GACGAGCTCCGGGACATGGCTGGGGGTGAGGAGTGA

Structures

Toxin

• AlphaFold DB: A0A0F7FTZ9