Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1433475..1433934 Replicon chromosome
Accession NZ_CP009913
Organism Streptococcus salivarius strain NCTC 8618

Toxin (Protein)


Gene name relE Uniprot ID A0A448ACE6
Locus tag SSAL8618_RS06880 Protein ID WP_038676362.1
Coordinates 1433475..1433729 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID F8LI53
Locus tag SSAL8618_RS06885 Protein ID WP_013990356.1
Coordinates 1433719..1433934 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSAL8618_RS06850 1428672..1429427 + 756 WP_038676355.1 ABC transporter permease -
SSAL8618_RS06855 1429479..1429874 - 396 WP_080730931.1 DUF4352 domain-containing protein -
SSAL8618_RS10560 1429894..1430052 - 159 WP_155274349.1 hypothetical protein -
SSAL8618_RS06860 1430199..1431074 - 876 WP_038676357.1 HAMP domain-containing histidine kinase -
SSAL8618_RS06865 1431074..1431757 - 684 WP_014632931.1 response regulator transcription factor -
SSAL8618_RS06870 1431921..1432553 - 633 WP_021143918.1 nitroreductase family protein -
SSAL8618_RS06875 1432644..1433330 - 687 WP_038676360.1 DUF1275 domain-containing protein -
SSAL8618_RS06880 1433475..1433729 - 255 WP_038676362.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SSAL8618_RS06885 1433719..1433934 - 216 WP_013990356.1 hypothetical protein Antitoxin
SSAL8618_RS06890 1434065..1434907 - 843 WP_038676364.1 aldo/keto reductase -
SSAL8618_RS06895 1435042..1436043 - 1002 WP_038676367.1 UDP-glucose 4-epimerase GalE -
SSAL8618_RS06900 1436155..1437765 - 1611 WP_038676369.1 alpha-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-57)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9876.63 Da        Isoelectric Point: 11.1183

>T50151 WP_038676362.1 NZ_CP009913:c1433729-1433475 [Streptococcus salivarius]
MTYKIVPTPKFAKSFKKLDPFVRKQIKSYLNRITDNPRAKGKALVANRTGQWRYRIGAYRVIVNIQDNELIILALEVGHR
RDIY

Download         Length: 255 bp

>T50151 NZ_CP009913:c1433729-1433475 [Streptococcus salivarius]
ATGACCTATAAGATAGTACCAACCCCTAAATTTGCCAAAAGTTTTAAAAAGTTGGATCCTTTTGTCAGGAAACAAATTAA
GTCTTATCTCAATCGTATCACAGATAATCCAAGAGCTAAGGGTAAGGCATTGGTTGCCAATCGAACTGGACAATGGCGCT
ATCGTATAGGTGCCTATCGTGTTATTGTCAATATTCAGGACAATGAACTAATCATACTTGCTCTCGAAGTTGGTCATAGA
CGTGATATCTATTAG

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8016.98 Da        Isoelectric Point: 3.8852

>AT50151 WP_013990356.1 NZ_CP009913:c1433934-1433719 [Streptococcus salivarius]
MTTITLKVSEADKKFMQAIAKFEGVSLSELIRTKTLDAIEDEYDARVADLALAEYEDYLENGGEVLNWDDL

Download         Length: 216 bp

>AT50151 NZ_CP009913:c1433934-1433719 [Streptococcus salivarius]
ATGACAACAATTACATTGAAGGTTTCAGAAGCAGATAAGAAGTTCATGCAGGCAATTGCGAAATTTGAAGGCGTATCCTT
GTCAGAATTAATTCGTACCAAGACTTTAGACGCCATTGAGGATGAATACGATGCTAGAGTAGCCGATTTGGCCTTAGCAG
AATATGAAGACTATCTTGAAAACGGTGGGGAGGTGCTAAATTGGGATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A448ACE6

Antitoxin

Source ID Structure
AlphaFold DB F8LI53

References