Detailed information of TA system TA050137

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /COG5642-COG5654
• Location: 290632..291598
• Replicon: chromosome
• Accession: NZ_CP009906
• Organism: Yersinia pestis Antiqua

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A0E8XJV6
• Locus tag: CH58_RS02425
• Protein ID: WP_002210981.1
• Coordinates: 291140..291598 (+)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A0E1NXA5
• Locus tag: CH58_RS02420
• Protein ID: WP_002220311.1
• Coordinates: 290632..291078 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CH58_RS02400	286222..287196	-	975	WP_002210985.1	L-Ala-D/L-Glu epimerase	-
CH58_RS02405	287359..287862	+	504	WP_002210984.1	thiol peroxidase	-
CH58_RS02410	288115..288573	+	459	WP_002213775.1	IS200/IS605-like element IS1541B family transposase	-
CH58_RS02415	288720..290297	-	1578	WP_002210983.1	transcriptional regulator TyrR	-
CH58_RS02420	290632..291078	+	447	WP_002220311.1	DUF2384 domain-containing protein	Antitoxin
CH58_RS02425	291140..291598	+	459	WP_002210981.1	RES family NAD+ phosphorylase	Toxin
CH58_RS02430	291608..292669	-	1062	WP_002210980.1	YcjF family protein	-
CH58_RS02435	292666..294063	-	1398	WP_002210979.1	YcjX family protein	-
CH58_RS02440	294044..294286	-	243	WP_002216375.1	phage shock protein PspD	-
CH58_RS02445	294371..294730	-	360	WP_002210977.1	envelope stress response membrane protein PspC	-
CH58_RS02450	294730..294957	-	228	WP_002210976.1	envelope stress response membrane protein PspB	-
CH58_RS02455	295119..295784	-	666	WP_002210975.1	phage shock protein PspA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	288115..288573	458

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (2-147)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (94-145)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 16994.38 Da
• Isoelectric Point: 4.8732

>T50137 WP_002210981.1 NZ_CP009906:291140-291598 [Yersinia pestis Antiqua]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSVGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Nucleotide

• Length: 459 bp

>T50137 NZ_CP009906:291140-291598 [Yersinia pestis Antiqua]
ATGACGCTATACCGCATTGTTATGCGCCGCTATCTTGCATCGGCATGGACTGGTTACGGCGCTGAAATCTATGGTGGTCG
TTGGAATCATAAAGGCCATGCTGCCATCTATTTAGCCAGCAGTATTTCATTGGCTATGCTCGAAACACTGGCACATATTC
AGGACAGTTCAACACTCAGCGAATTTGAATTATTCCAAATTGAAATCAGTGACAGCAGTATTATGTTGCTACAGCCGCAG
GACTGGCCCACGGATTGGCGTAGCGATCCGGCACCGGTGGCAACGATGGATGTCGGCACCGAGTGGCTGGAATCAGAATC
CTCGGTAGGCTTACTGGTCCCGTCCACGTTGGTGCCGTCAGAAAACAACCTACTGGTCAATCCTCATCACAAAGATTTTC
CAGCGTGTTTGGCCAGCGTCAAACCGCTCTCTTTTGTCTTTGATCCACGGTTAAAATAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16332.83 Da
• Isoelectric Point: 9.0335

>AT50137 WP_002220311.1 NZ_CP009906:290632-291078 [Yersinia pestis Antiqua]
MRAYRPNPATKMGTLWSEIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Nucleotide

• Length: 447 bp

>AT50137 NZ_CP009906:290632-291078 [Yersinia pestis Antiqua]
ATGAGAGCGTACCGCCCAAACCCCGCGACTAAAATGGGAACGCTTTGGAGTGAAATTGGCTTACCCGCCAGCCGCGGCAC
GATATTGGTCGATAGTATCAAAATGGGGTTTTCTGTTGATGTTATCGACAGCATTCATTTATGGGCATCCATGCCTAAAG
CTGAAATATTACGTGCTACCGGTATCCCCAGCCGTAGCCTGACTCGCCGCCGCACACATGATGGCCGTTTTACGCCTGAA
GAAAGCGAGAGAATCGCACGTTTTGTCCGCGTAATGGATGCCGCTGTCGATTTGTTCGGCGGCGATAAAGGTAAAGCCAT
TACCTGGATGTCCACGCCCATCAAAGGATTGGGGTACCGCAGCCCAGACTCCTTACTGGAAACCGAAACTGGCGCACTGG
AAGTGTGTGATTTGATTGGTCGTTTGGAACACGGCGTCTTTACTTAA

Structures

Toxin

• AlphaFold DB: A0A0E8XJV6

Antitoxin

• AlphaFold DB: A0A0E1NXA5