Detailed information of TA system TA050130

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 5419264..5419898
• Replicon: chromosome
• Accession: NZ_CP009896
• Organism: Pimelobacter simplex strain VKM Ac-2033D

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: KR76_RS26540
• Protein ID: WP_038682640.1
• Coordinates: 5419264..5419680 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A0A1DVH0
• Locus tag: KR76_RS26545
• Protein ID: WP_038682642.1
• Coordinates: 5419671..5419898 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KR76_RS26525	5414309..5415955	+	1647	WP_038682638.1	ABC transporter ATP-binding protein	-
KR76_RS26530	5416087..5416911	+	825	WP_200887233.1	formylglycine-generating enzyme family protein	-
KR76_RS26535	5416908..5419274	+	2367	WP_082003854.1	arylsulfatase	-
KR76_RS26540	5419264..5419680	-	417	WP_038682640.1	PIN domain-containing protein	Toxin
KR76_RS26545	5419671..5419898	-	228	WP_038682642.1	hypothetical protein	Antitoxin
KR76_RS26550	5419932..5421893	-	1962	WP_038682644.1	AarF/ABC1/UbiB kinase family protein	-
KR76_RS26555	5421957..5422481	-	525	WP_038682646.1	TetR/AcrR family transcriptional regulator	-
KR76_RS26560	5422483..5423691	-	1209	WP_038682648.1	cytochrome P450	-
KR76_RS26565	5423753..5424286	-	534	WP_038682650.1	DNA starvation/stationary phase protection protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Ribbon-helix-helix protein, CopG (9-40)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 15239.55 Da
• Isoelectric Point: 6.0858

>T50130 WP_038682640.1 NZ_CP009896:c5419680-5419264 [Pimelobacter simplex]
MVVTHWLVDKSALVRLAHAAERDEWLERCRRGLVRITSPTLLETGFSARSADDWQALVTGPPVSWFPVEYLTPAVERRAL
DVQRILAARGQHRAPSVPDLLIAAAAELAGLVVLHLDKDFELIADVTGQQVERLAVTA

Nucleotide

• Length: 417 bp

>T50130 NZ_CP009896:c5419680-5419264 [Pimelobacter simplex]
CTGGTCGTGACCCACTGGCTGGTCGACAAGTCGGCCCTCGTCCGGCTGGCGCACGCCGCCGAGCGCGACGAATGGCTCGA
GCGCTGTCGCCGTGGCCTGGTCCGGATCACCTCCCCGACGCTGCTCGAGACGGGCTTCTCGGCGCGCTCCGCCGACGACT
GGCAGGCGCTGGTCACCGGACCGCCCGTGTCGTGGTTCCCCGTCGAGTACCTCACCCCTGCTGTCGAGCGCCGCGCGCTC
GACGTCCAGCGGATCCTCGCGGCCCGGGGCCAGCACCGCGCGCCCTCGGTGCCCGACCTGCTGATCGCCGCGGCGGCCGA
GCTGGCGGGGCTCGTGGTGCTTCACCTCGACAAGGACTTCGAGCTGATCGCGGACGTCACCGGCCAGCAGGTCGAGCGCC
TCGCGGTCACTGCGTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8526.44 Da
• Isoelectric Point: 4.2447

>AT50130 WP_038682642.1 NZ_CP009896:c5419898-5419671 [Pimelobacter simplex]
MTDLLIRNVSDDDLRRIDDKARRLGLSRADYFRRLIVQEAARGVDDAEPGADVFARFADLAQDLGDDDVMRDAWS

Nucleotide

• Length: 228 bp

>AT50130 NZ_CP009896:c5419898-5419671 [Pimelobacter simplex]
ATGACCGACCTGCTCATCCGGAACGTGTCTGACGACGACCTGCGGCGGATCGACGACAAGGCCCGCCGGCTCGGCCTGTC
GCGGGCCGACTACTTCCGCCGGCTGATCGTCCAGGAGGCGGCACGCGGGGTCGACGACGCCGAACCGGGCGCCGACGTCT
TCGCGCGGTTCGCCGACCTCGCCCAGGACCTCGGCGACGACGACGTGATGCGGGACGCCTGGTCGTGA

Structures

Antitoxin

• AlphaFold DB: A0A0A1DVH0