Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 340740..341395 Replicon chromosome
Accession NZ_CP009896
Organism Pimelobacter simplex strain VKM Ac-2033D

Toxin (Protein)


Gene name vapC Uniprot ID A0A0A1DF14
Locus tag KR76_RS01585 Protein ID WP_038676143.1
Coordinates 340740..341126 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0A1DK85
Locus tag KR76_RS01590 Protein ID WP_038676145.1
Coordinates 341123..341395 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KR76_RS01565 337233..337628 - 396 WP_038676142.1 hypothetical protein -
KR76_RS01570 337625..338440 - 816 WP_082003502.1 LytTR family DNA-binding domain-containing protein -
KR76_RS01575 338437..339567 - 1131 WP_038683164.1 histidine kinase -
KR76_RS01580 339686..340693 - 1008 WP_075018681.1 class I SAM-dependent methyltransferase -
KR76_RS01585 340740..341126 - 387 WP_038676143.1 type II toxin-antitoxin system VapC family toxin Toxin
KR76_RS01590 341123..341395 - 273 WP_038676145.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
KR76_RS01595 341467..342195 + 729 WP_038676146.1 hypothetical protein -
KR76_RS01600 342486..343304 - 819 WP_038676148.1 HAD-IB family hydrolase -
KR76_RS01605 343427..344536 + 1110 WP_075018682.1 CpaE-like family protein -
KR76_RS01610 344536..345747 + 1212 WP_082003503.1 TadA family conjugal transfer-associated ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-123)

Antitoxin

Antitoxin VapB-like

(1-88)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 13718.63 Da        Isoelectric Point: 6.4662

>T50129 WP_038676143.1 NZ_CP009896:c341126-340740 [Pimelobacter simplex]
MIVDTSALIAVLFAEKEASDFADLMAAQPARVSAANWVEATMVADGKRVAAGDRLDRLMGELGVTIEPVTETHARAARIA
FRRYGRGSGSPARLNFGDCFAYALSATSGEPLLFKGVDFTHTDVLRAR

Download         Length: 387 bp

>T50129 NZ_CP009896:c341126-340740 [Pimelobacter simplex]
ATGATCGTCGACACCTCGGCCCTGATCGCGGTCCTCTTCGCGGAGAAGGAGGCCTCCGACTTCGCCGACCTGATGGCAGC
GCAGCCGGCGCGGGTCTCGGCGGCGAACTGGGTCGAGGCGACGATGGTGGCCGACGGGAAGCGGGTCGCCGCGGGCGACC
GGCTCGACCGGTTGATGGGCGAGCTCGGCGTCACCATCGAGCCGGTCACCGAGACCCACGCACGGGCGGCCCGGATCGCC
TTCCGTCGCTACGGTCGCGGGTCCGGCTCACCGGCCCGGCTCAACTTCGGTGACTGCTTCGCGTACGCGCTGAGCGCCAC
CTCGGGTGAGCCGCTGCTCTTCAAGGGGGTGGACTTCACGCACACTGACGTCCTGCGCGCCCGCTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9965.11 Da        Isoelectric Point: 4.5716

>AT50129 WP_038676145.1 NZ_CP009896:c341395-341123 [Pimelobacter simplex]
MSLNIKNERVHALAREAARVTGKTQTSAIEEALELLLKNYGSDPVAADRERRLDAIHRIQVEVADLPATAGDDRIREEND
LYDPETGLPA

Download         Length: 273 bp

>AT50129 NZ_CP009896:c341395-341123 [Pimelobacter simplex]
ATGAGCCTGAACATCAAGAACGAGCGGGTGCACGCGCTCGCCCGCGAGGCGGCGCGGGTGACCGGCAAGACCCAGACGAG
TGCGATCGAGGAGGCGTTGGAGTTGCTGCTGAAGAACTACGGGAGCGACCCGGTGGCTGCCGACCGGGAGCGGCGGCTCG
ACGCGATCCACCGCATCCAGGTGGAGGTGGCCGACCTACCCGCCACAGCCGGGGACGACCGGATCCGCGAGGAGAACGAC
CTGTACGACCCGGAGACGGGCCTGCCCGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A1DF14

Antitoxin

Source ID Structure
AlphaFold DB A0A0A1DK85

References