Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 2790990..2791601 Replicon chromosome
Accession NZ_CP009885
Organism Xylella fastidiosa strain Hib4

Toxin (Protein)


Gene name relE Uniprot ID A0A1L2AQ84
Locus tag XFHB_RS13665 Protein ID WP_060871756.1
Coordinates 2791302..2791601 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9P9V8
Locus tag XFHB_RS13660 Protein ID WP_010895177.1
Coordinates 2790990..2791298 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XFHB_RS14390 2786823..2787065 - 243 WP_157293276.1 hypothetical protein -
XFHB_RS13625 2787565..2788326 - 762 WP_010895174.1 Bax inhibitor-1/YccA family protein -
XFHB_RS13655 2789522..2790916 + 1395 WP_088578038.1 hypothetical protein -
XFHB_RS13660 2790990..2791298 - 309 WP_010895177.1 putative addiction module antidote protein Antitoxin
XFHB_RS13665 2791302..2791601 - 300 WP_060871756.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
XFHB_RS13670 2791685..2792455 + 771 WP_088578521.1 hypothetical protein -
XFHB_RS14395 2792608..2792877 - 270 Protein_2507 hemagglutinin-related protein -
XFHB_RS13680 2793041..2793433 - 393 WP_046420955.1 DUF596 domain-containing protein -
XFHB_RS13685 2793443..2794579 - 1137 WP_088578634.1 DUF769 domain-containing protein -
XFHB_RS13690 2794984..2795378 - 395 Protein_2510 DUF596 domain-containing protein -
XFHB_RS13695 2795390..2795722 - 333 WP_167701502.1 DUF769 domain-containing protein -
XFHB_RS13700 2795894..2796286 - 393 WP_060872241.1 DUF596 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2782841..2792721 9880


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-98)

Antitoxin

Uncharacterized protein HI1420

(15-100)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11436.20 Da        Isoelectric Point: 10.1713

>T50126 WP_060871756.1 NZ_CP009885:c2791601-2791302 [Xylella fastidiosa]
MTYTVKRLEEFSDWLKGLKDGLARQRLIKRLRKVQLGNFGDVQPVGEGVFEMREHFGPGWRMYYVQRGSFLIVMLGGGDK
STQQSDIRRAIELAKSLED

Download         Length: 300 bp

>T50126 NZ_CP009885:c2791601-2791302 [Xylella fastidiosa]
ATGACCTACACGGTGAAACGACTCGAAGAGTTCTCTGACTGGCTAAAGGGCCTGAAGGATGGGCTGGCAAGGCAGCGCCT
CATCAAGCGCTTACGCAAGGTGCAGCTCGGCAACTTTGGAGACGTGCAGCCGGTGGGTGAAGGCGTGTTTGAGATGCGCG
AACACTTCGGACCTGGCTGGCGTATGTACTACGTGCAGCGAGGCAGCTTTCTCATCGTGATGCTCGGTGGCGGCGACAAG
TCAACGCAACAATCAGACATTCGTCGGGCCATTGAGCTAGCAAAATCTTTGGAGGATTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11038.60 Da        Isoelectric Point: 4.6561

>AT50126 WP_010895177.1 NZ_CP009885:c2791298-2790990 [Xylella fastidiosa]
VTITKKINVSELPEFDAAEYLSSEEEVAAYLTAVLEENDPALLAAALGDIARSRGMSQIAKDSGITREGLYKALRPGSEP
RFDTISRVCTALGIRLVAQPMR

Download         Length: 309 bp

>AT50126 NZ_CP009885:c2791298-2790990 [Xylella fastidiosa]
GTGACCATCACCAAGAAAATCAATGTCTCCGAACTGCCAGAGTTCGATGCCGCCGAATACCTGAGCAGCGAGGAGGAGGT
AGCCGCGTATCTCACGGCTGTTCTTGAAGAAAACGATCCAGCACTGTTAGCGGCTGCGCTGGGTGACATTGCCCGTTCAC
GTGGCATGTCTCAGATTGCGAAGGATTCCGGCATCACGCGGGAAGGTCTATACAAGGCCCTTCGGCCTGGCAGTGAACCA
CGCTTCGATACGATAAGCCGCGTCTGTACCGCCCTCGGTATACGTCTAGTAGCGCAACCAATGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L2AQ84

Antitoxin

Source ID Structure
AlphaFold DB A0A1S0V409

References