50125

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 2511611..2512142 Replicon chromosome
Accession NZ_CP009885
Organism Xylella fastidiosa strain Hib4

Toxin (Protein)


Gene name relE Uniprot ID A0A1L2ALG3
Locus tag XFHB_RS12370 Protein ID WP_060872142.1
Coordinates 2511861..2512142 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A1L2ALQ3
Locus tag XFHB_RS12365 Protein ID WP_060872141.1
Coordinates 2511611..2511874 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XFHB_RS12340 2506837..2508015 - 1179 WP_088577846.1 phage tail sheath family protein -
XFHB_RS12345 2508080..2509672 - 1593 WP_088577845.1 tail fiber domain-containing protein -
XFHB_RS12350 2509680..2510237 - 558 WP_088577844.1 phage tail protein I -
XFHB_RS12355 2510230..2511123 - 894 WP_088577843.1 baseplate J/gp47 family protein -
XFHB_RS12360 2511123..2511461 - 339 WP_042462908.1 GPW/gp25 family protein -
XFHB_RS12365 2511611..2511874 + 264 WP_060872141.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
XFHB_RS12370 2511861..2512142 + 282 WP_060872142.1 type II toxin-antitoxin system YafQ family toxin Toxin
XFHB_RS12375 2512188..2512775 - 588 WP_088578420.1 phage baseplate assembly protein V -
XFHB_RS12380 2512772..2513314 - 543 WP_088578421.1 hypothetical protein -
XFHB_RS12385 2513290..2513811 - 522 WP_088578422.1 hypothetical protein -
XFHB_RS12390 2513808..2514131 - 324 WP_088578423.1 hypothetical protein -
XFHB_RS12395 2514131..2514391 - 261 WP_088578424.1 hypothetical protein -
XFHB_RS12400 2514409..2516289 - 1881 WP_088578425.1 phage major capsid protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2501127..2542389 41262


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-84)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10873.32 Da        Isoelectric Point: 7.5805

>T50125 WP_060872142.1 NZ_CP009885:2511861-2512142 [Xylella fastidiosa]
MRRISQTGQFKRDYKREAKGQHRATLDEELIHVVHALACDHPLEPRHHDHALTGSWKDHRDCHIKPDLVLIYRKPDDETL
QLVRIGSHSELGL

Download         Length: 282 bp

>T50125 NZ_CP009885:2511861-2512142 [Xylella fastidiosa]
ATGCGGAGGATTAGCCAGACTGGCCAGTTCAAGCGCGACTACAAGCGCGAAGCTAAGGGCCAGCATCGCGCCACGCTTGA
TGAGGAACTCATACACGTCGTGCATGCCTTAGCCTGTGATCATCCGTTGGAGCCACGCCACCACGATCACGCACTGACTG
GCAGCTGGAAAGATCACCGTGATTGCCACATCAAACCCGACTTGGTACTGATATACCGGAAGCCAGACGACGAGACATTG
CAGCTCGTGCGCATTGGCTCACACAGCGAACTAGGTTTGTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9437.91 Da        Isoelectric Point: 6.2180

>AT50125 WP_060872141.1 NZ_CP009885:2511611-2511874 [Xylella fastidiosa]
MSANAVVRARVDAHIKEEASTVLATMGLSVSDAFRMMLTRIAREKALPFEPLVPNATTIAAMREARAGHLKSFDSIEALM
ADLHAED

Download         Length: 264 bp

>AT50125 NZ_CP009885:2511611-2511874 [Xylella fastidiosa]
ATGTCTGCAAACGCAGTTGTCCGTGCCCGCGTTGACGCGCACATCAAAGAAGAAGCATCAACCGTACTGGCGACGATGGG
CCTAAGCGTGTCTGATGCGTTCCGCATGATGCTGACCCGCATTGCTCGCGAGAAGGCACTACCGTTCGAGCCGCTGGTGC
CGAACGCAACTACCATCGCAGCCATGCGCGAAGCCCGCGCTGGTCACCTCAAGAGCTTTGACAGCATTGAGGCGCTCATG
GCGGACTTGCATGCGGAGGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L2ALG3

Antitoxin

Source ID Structure
AlphaFold DB A0A1L2ALQ3

References