Detailed information of TA system TA050123

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumAB/COG3657-dnstrm_HI1420
• Location: 1657505..1658097
• Replicon: chromosome
• Accession: NZ_CP009885
• Organism: Xylella fastidiosa strain Hib4

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: Q9PD07
• Locus tag: XFHB_RS08385
• Protein ID: WP_010894094.1
• Coordinates: 1657505..1657801 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: -
• Locus tag: XFHB_RS08390
• Protein ID: WP_004085592.1
• Coordinates: 1657804..1658097 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
XFHB_RS08355	1653043..1653534	-	492	WP_171817079.1	glutathione peroxidase	-
XFHB_RS14295	1653987..1654148	-	162	WP_010894100.1	hypothetical protein	-
XFHB_RS08365	1654367..1655242	+	876	WP_023906641.1	ABC transporter ATP-binding protein	-
XFHB_RS08370	1655239..1656216	+	978	WP_088578153.1	ABC transporter permease	-
XFHB_RS08375	1656458..1656904	+	447	WP_031336674.1	hypothetical protein	-
XFHB_RS08380	1657094..1657313	-	220	Protein_1551	tail fiber protein	-
XFHB_RS08385	1657505..1657801	+	297	WP_010894094.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
XFHB_RS08390	1657804..1658097	+	294	WP_004085592.1	putative addiction module antidote protein	Antitoxin
XFHB_RS08395	1658153..1658506	-	354	WP_088578042.1	hypothetical protein	-
XFHB_RS08400	1658503..1658883	-	381	Protein_1555	hypothetical protein	-
XFHB_RS08405	1659421..1660437	+	1017	WP_060870179.1	peptidase M4 family protein	-
XFHB_RS08410	1660445..1660798	+	354	WP_081089730.1	hypothetical protein	-
XFHB_RS08415	1660822..1661094	+	273	WP_088372204.1	helix-turn-helix domain-containing protein	-
XFHB_RS08420	1661066..1661632	+	567	WP_088578154.1	SocA family protein	-
XFHB_RS08425	1661632..1661859	+	228	WP_023906515.1	hypothetical protein	-
XFHB_RS08430	1661860..1663023	-	1164	WP_088578045.1	phage tail protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1657505..1686114	28609

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (1-94)

Antitoxin

• Uncharacterized protein HI1420 (3-93)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11167.73 Da
• Isoelectric Point: 9.8173

>T50123 WP_010894094.1 NZ_CP009885:1657505-1657801 [Xylella fastidiosa]
MIELKQTDTFRKWREKLKDARARSAIASRLDRLAFGHVGDAEPVGKGVSELRINYGPGYRVYFQQRGDTIYLLLCGGDKG
LQARDIKTALHLSEQWSE

Nucleotide

• Length: 297 bp

>T50123 NZ_CP009885:1657505-1657801 [Xylella fastidiosa]
ATGATTGAATTGAAGCAGACTGACACCTTCCGCAAGTGGCGGGAGAAACTCAAGGATGCGCGCGCCCGCTCGGCCATCGC
CTCACGCCTCGACCGCTTGGCGTTCGGCCATGTCGGCGACGCCGAGCCAGTAGGGAAAGGTGTCAGCGAGCTTCGCATCA
ACTACGGCCCCGGTTACCGGGTGTATTTCCAGCAGCGTGGCGACACGATCTACTTGCTACTTTGCGGCGGTGACAAAGGA
TTACAAGCGCGTGACATCAAGACTGCGCTGCACCTCTCTGAACAATGGAGCGAATGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10246.59 Da
• Isoelectric Point: 5.6232

>AT50123 WP_004085592.1 NZ_CP009885:1657804-1658097 [Xylella fastidiosa]
MTEKLTSYDPAEDLTTDQAIADFMAAAFGTNDPAYVAHALGVVARAKGMTQIASQTGLSREQLYRSFSAEGNPTLRTTLA
VMKALGIELSAKPSGVH

Nucleotide

• Length: 294 bp

>AT50123 NZ_CP009885:1657804-1658097 [Xylella fastidiosa]
ATGACCGAGAAACTGACGAGCTACGATCCGGCCGAGGACTTGACCACTGACCAGGCCATCGCCGATTTCATGGCAGCCGC
GTTCGGGACGAACGATCCTGCCTACGTTGCCCACGCGCTGGGCGTCGTTGCCCGCGCCAAGGGCATGACGCAGATCGCCA
GCCAGACAGGGCTATCGCGCGAACAGCTCTACCGCTCGTTCAGTGCCGAGGGCAACCCGACGCTGCGCACGACATTAGCC
GTGATGAAGGCGCTAGGGATCGAGCTCTCTGCGAAACCGTCTGGTGTTCACTGA

Structures

Toxin

• AlphaFold DB: A0A1S0V711