Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 1568127..1568719 Replicon chromosome
Accession NZ_CP009885
Organism Xylella fastidiosa strain Hib4

Toxin (Protein)


Gene name PumA Uniprot ID Q9PD07
Locus tag XFHB_RS07840 Protein ID WP_010894094.1
Coordinates 1568127..1568423 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag XFHB_RS07845 Protein ID WP_004085592.1
Coordinates 1568426..1568719 (+) Length 98 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XFHB_RS07810 1563665..1564156 - 492 WP_171817079.1 glutathione peroxidase -
XFHB_RS14280 1564609..1564770 - 162 WP_010894100.1 hypothetical protein -
XFHB_RS07820 1564989..1565864 + 876 WP_023906641.1 ABC transporter ATP-binding protein -
XFHB_RS07825 1565861..1566838 + 978 WP_088578153.1 ABC transporter permease -
XFHB_RS07830 1567080..1567526 + 447 WP_031336674.1 hypothetical protein -
XFHB_RS07835 1567716..1567935 - 220 Protein_1446 tail fiber protein -
XFHB_RS07840 1568127..1568423 + 297 WP_010894094.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
XFHB_RS07845 1568426..1568719 + 294 WP_004085592.1 putative addiction module antidote protein Antitoxin
XFHB_RS07850 1568775..1569128 - 354 WP_088578042.1 hypothetical protein -
XFHB_RS07855 1569125..1569505 - 381 Protein_1450 hypothetical protein -
XFHB_RS07860 1570043..1571059 + 1017 WP_060870179.1 peptidase M4 family protein -
XFHB_RS07865 1571067..1571420 + 354 WP_081089730.1 hypothetical protein -
XFHB_RS07870 1571444..1571716 + 273 WP_088372204.1 helix-turn-helix domain-containing protein -
XFHB_RS07875 1571688..1572254 + 567 WP_088578154.1 SocA family protein -
XFHB_RS07880 1572254..1572481 + 228 WP_023906515.1 hypothetical protein -
XFHB_RS07885 1572482..1573645 - 1164 WP_088578045.1 phage tail protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1568127..1612354 44227


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 99 a.a.        Molecular weight: 11167.73 Da        Isoelectric Point: 9.8173

>T50121 WP_010894094.1 NZ_CP009885:1568127-1568423 [Xylella fastidiosa]
MIELKQTDTFRKWREKLKDARARSAIASRLDRLAFGHVGDAEPVGKGVSELRINYGPGYRVYFQQRGDTIYLLLCGGDKG
LQARDIKTALHLSEQWSE

Download         Length: 297 bp

>T50121 NZ_CP009885:1568127-1568423 [Xylella fastidiosa]
ATGATTGAATTGAAGCAGACTGACACCTTCCGCAAGTGGCGGGAGAAACTCAAGGATGCGCGCGCCCGCTCGGCCATCGC
CTCACGCCTCGACCGCTTGGCGTTCGGCCATGTCGGCGACGCCGAGCCAGTAGGGAAAGGTGTCAGCGAGCTTCGCATCA
ACTACGGCCCCGGTTACCGGGTGTATTTCCAGCAGCGTGGCGACACGATCTACTTGCTACTTTGCGGCGGTGACAAAGGA
TTACAAGCGCGTGACATCAAGACTGCGCTGCACCTCTCTGAACAATGGAGCGAATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10246.59 Da        Isoelectric Point: 5.6232

>AT50121 WP_004085592.1 NZ_CP009885:1568426-1568719 [Xylella fastidiosa]
MTEKLTSYDPAEDLTTDQAIADFMAAAFGTNDPAYVAHALGVVARAKGMTQIASQTGLSREQLYRSFSAEGNPTLRTTLA
VMKALGIELSAKPSGVH

Download         Length: 294 bp

>AT50121 NZ_CP009885:1568426-1568719 [Xylella fastidiosa]
ATGACCGAGAAACTGACGAGCTACGATCCGGCCGAGGACTTGACCACTGACCAGGCCATCGCCGATTTCATGGCAGCCGC
GTTCGGGACGAACGATCCTGCCTACGTTGCCCACGCGCTGGGCGTCGTTGCCCGCGCCAAGGGCATGACGCAGATCGCCA
GCCAGACAGGGCTATCGCGCGAACAGCTCTACCGCTCGTTCAGTGCCGAGGGCAACCCGACGCTGCGCACGACATTAGCC
GTGATGAAGGCGCTAGGGATCGAGCTCTCTGCGAAACCGTCTGGTGTTCACTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A1S0V711


Antitoxin

Source ID Structure

References