50120

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 1383379..1383856 Replicon chromosome
Accession NZ_CP009885
Organism Xylella fastidiosa strain Hib4

Toxin (Protein)


Gene name pasB Uniprot ID A0A1L2B0S8
Locus tag XFHB_RS06810 Protein ID WP_023907681.1
Coordinates 1383379..1383645 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID A0A1L2AR28
Locus tag XFHB_RS06815 Protein ID WP_031336679.1
Coordinates 1383629..1383856 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XFHB_RS06780 1378915..1379868 + 954 WP_088578037.1 bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA -
XFHB_RS06785 1379865..1380593 + 729 WP_010894264.1 type III pantothenate kinase -
XFHB_RS06790 1380604..1381230 + 627 WP_010894263.1 SPOR domain-containing protein -
XFHB_RS06805 1381973..1383367 + 1395 WP_088578038.1 hypothetical protein -
XFHB_RS06810 1383379..1383645 - 267 WP_023907681.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
XFHB_RS06815 1383629..1383856 - 228 WP_031336679.1 CopG family transcriptional regulator Antitoxin
XFHB_RS06820 1383967..1384737 + 771 WP_088578039.1 hypothetical protein -
XFHB_RS06825 1384737..1385030 + 294 WP_088578040.1 hypothetical protein -
XFHB_RS06830 1385027..1385857 + 831 WP_023906521.1 hypothetical protein -
XFHB_RS06835 1385854..1386495 + 642 WP_088578041.1 hypothetical protein -
XFHB_RS06840 1386492..1386845 + 354 WP_088578042.1 hypothetical protein -
XFHB_RS06845 1386938..1388083 + 1146 WP_088578043.1 baseplate J/gp47 family protein -
XFHB_RS06850 1388080..1388640 + 561 WP_088578044.1 DUF2612 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10176.88 Da        Isoelectric Point: 10.9777

>T50120 WP_023907681.1 NZ_CP009885:c1383645-1383379 [Xylella fastidiosa]
MAWTIDYTDTAKQQLRKLDKHMARRIVDFMDERIAGLENPRSTGKALTGPLGGFWRYRVGDFRVVCAIQDSVLRVLVVRV
GHRGKIYR

Download         Length: 267 bp

>T50120 NZ_CP009885:c1383645-1383379 [Xylella fastidiosa]
TTGGCCTGGACGATTGATTACACCGACACGGCCAAGCAGCAGTTACGCAAACTCGACAAGCACATGGCGCGGCGCATTGT
CGATTTCATGGATGAGCGCATCGCCGGACTAGAAAACCCACGCAGCACTGGTAAAGCATTAACCGGACCACTTGGCGGCT
TTTGGCGTTATCGTGTTGGTGATTTCCGGGTCGTCTGCGCCATTCAAGATAGCGTTTTGCGCGTCCTTGTAGTGCGTGTT
GGTCACCGGGGTAAGATTTACCGATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8691.73 Da        Isoelectric Point: 5.0958

>AT50120 WP_031336679.1 NZ_CP009885:c1383856-1383629 [Xylella fastidiosa]
MATSIRLSPEMEQRLNYLASHTGRTKAYYLREIIEHGIEEMEDYYLAADVLERVRHGQEQVHSAADVRKTLGLDD

Download         Length: 228 bp

>AT50120 NZ_CP009885:c1383856-1383629 [Xylella fastidiosa]
ATGGCGACTTCGATTCGCCTCTCTCCTGAAATGGAGCAAAGGCTGAACTATCTTGCCTCCCATACGGGACGCACAAAGGC
TTACTACCTGCGTGAAATCATTGAGCATGGCATTGAGGAAATGGAGGATTACTACCTTGCTGCCGATGTATTGGAGCGTG
TCCGTCATGGACAAGAACAGGTGCATTCTGCTGCCGACGTGAGGAAAACGCTTGGCCTGGACGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L2B0S8

Antitoxin

Source ID Structure
AlphaFold DB A0A1L2AR28

References