Detailed information of TA system TA050115

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-dinJ/YafQ-RelB
• Location: 1086551..1087079
• Replicon: chromosome
• Accession: NZ_CP009885
• Organism: Xylella fastidiosa strain Hib4

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: XFHB_RS05170
• Protein ID: WP_023906426.1
• Coordinates: 1086798..1087079 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: A0A1S0V873
• Locus tag: XFHB_RS05165
• Protein ID: WP_023906425.1
• Coordinates: 1086551..1086811 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
XFHB_RS05155	1082306..1085368	+	3063	WP_088577919.1	efflux RND transporter permease subunit	-
XFHB_RS05160	1085414..1086220	+	807	WP_088577920.1	oxidoreductase	-
XFHB_RS05165	1086551..1086811	+	261	WP_023906425.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
XFHB_RS05170	1086798..1087079	+	282	WP_023906426.1	type II toxin-antitoxin system YafQ family toxin	Toxin
XFHB_RS05180	1087476..1088510	-	1035	WP_023906427.1	serine protease	-
XFHB_RS05185	1088675..1088761	-	87	Protein_942	transposase	-
XFHB_RS05190	1089248..1089499	+	252	WP_010894487.1	antitoxin	-
XFHB_RS05195	1089496..1089804	+	309	WP_010894488.1	type II toxin-antitoxin system RelE/ParE family toxin	-
XFHB_RS14190	1089979..1090785	+	807	WP_157293241.1	hypothetical protein	-
XFHB_RS14195	1090808..1091044	+	237	WP_157293242.1	hypothetical protein	-
XFHB_RS05210	1091127..1091399	+	273	WP_088577921.1	DUF1778 domain-containing protein	-
XFHB_RS05215	1091396..1091881	+	486	WP_088577922.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-68)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10697.42 Da
• Isoelectric Point: 9.0869

>T50115 WP_023906426.1 NZ_CP009885:1086798-1087079 [Xylella fastidiosa]
VREIKQLGQFKRDLKREAKGQHRATLEDDLLPVIDALAKDMPLEPRHRDHALVGNWKDLRDCHIKPDLVLIYTRVDSKTL
TLVRLGSHAELGL

Nucleotide

• Length: 282 bp

>T50115 NZ_CP009885:1086798-1087079 [Xylella fastidiosa]
GTGCGGGAAATTAAACAACTCGGGCAGTTCAAACGTGACTTGAAGCGCGAAGCCAAGGGGCAGCATCGCGCCACGCTGGA
AGACGACCTGCTGCCCGTGATCGATGCCCTTGCTAAGGACATGCCCCTTGAGCCTCGGCACAGAGATCACGCACTGGTTG
GCAACTGGAAAGACCTTCGTGATTGTCACATCAAGCCCGACCTAGTCCTGATCTACACGCGGGTGGATAGCAAAACGCTG
ACGCTCGTCCGTCTCGGCTCCCATGCGGAACTCGGGCTGTAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 8983.55 Da
• Isoelectric Point: 10.5972

>AT50115 WP_023906425.1 NZ_CP009885:1086551-1086811 [Xylella fastidiosa]
MAANQLVQARIDGAIKAEATVVLAAMGLTVSDAVRLLLTKVAQDKALPFEPLIPNATTIKAMREARAGKGETVTLGELRA
TIRAGN

Nucleotide

• Length: 261 bp

>AT50115 NZ_CP009885:1086551-1086811 [Xylella fastidiosa]
ATGGCTGCGAATCAGCTTGTGCAAGCGCGCATCGATGGTGCGATCAAGGCAGAGGCAACCGTGGTACTGGCGGCGATGGG
GTTGACCGTTTCCGATGCGGTTCGGCTGTTGCTCACGAAGGTGGCTCAGGACAAGGCGTTGCCTTTTGAGCCGCTAATCC
CTAATGCCACCACCATCAAGGCCATGCGGGAGGCTCGTGCAGGTAAGGGCGAGACCGTCACGCTGGGTGAACTTCGAGCG
ACTATCCGTGCGGGAAATTAA

Structures

Antitoxin

• AlphaFold DB: A0A1S0V873