Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4332405..4333062 Replicon chromosome
Accession NZ_CP009876
Organism Klebsiella pneumoniae subsp. pneumoniae strain KPNIH31

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag KPNIH31_RS21370 Protein ID WP_002916310.1
Coordinates 4332405..4332815 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag KPNIH31_RS21375 Protein ID WP_002916312.1
Coordinates 4332796..4333062 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KPNIH31_RS21350 4328405..4330138 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
KPNIH31_RS21355 4330144..4330857 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KPNIH31_RS21360 4330880..4331776 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
KPNIH31_RS21365 4331877..4332398 + 522 WP_004144730.1 flavodoxin FldB -
KPNIH31_RS21370 4332405..4332815 - 411 WP_002916310.1 protein YgfX Toxin
KPNIH31_RS21375 4332796..4333062 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
KPNIH31_RS21380 4333308..4334291 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
KPNIH31_RS21385 4334442..4335101 - 660 WP_002916317.1 hemolysin III family protein -
KPNIH31_RS21390 4335265..4335576 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
KPNIH31_RS21395 4335626..4336354 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
KPNIH31_RS21400 4336473..4337906 + 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T50109 WP_002916310.1 NZ_CP009876:c4332815-4332405 [Klebsiella pneumoniae subsp. pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T50109 NZ_CP009876:c4332815-4332405 [Klebsiella pneumoniae subsp. pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT50109 WP_002916312.1 NZ_CP009876:c4333062-4332796 [Klebsiella pneumoniae subsp. pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT50109 NZ_CP009876:c4333062-4332796 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References