Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1116273..1116789 Replicon chromosome
Accession NZ_CP009876
Organism Klebsiella pneumoniae subsp. pneumoniae strain KPNIH31

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag KPNIH31_RS05410 Protein ID WP_009486548.1
Coordinates 1116273..1116557 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag KPNIH31_RS05415 Protein ID WP_002886901.1
Coordinates 1116547..1116789 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KPNIH31_RS05380 1111690..1111998 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
KPNIH31_RS29760 1112083..1112256 + 174 WP_032433782.1 hypothetical protein -
KPNIH31_RS05390 1112259..1113002 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
KPNIH31_RS05400 1113359..1115497 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
KPNIH31_RS05405 1115805..1116269 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KPNIH31_RS05410 1116273..1116557 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KPNIH31_RS05415 1116547..1116789 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KPNIH31_RS05420 1116867..1118777 - 1911 WP_009486549.1 BglG family transcription antiterminator -
KPNIH31_RS05425 1118800..1119954 - 1155 WP_002886900.1 lactonase family protein -
KPNIH31_RS05430 1120021..1120761 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T50096 WP_009486548.1 NZ_CP009876:c1116557-1116273 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T50096 NZ_CP009876:c1116557-1116273 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCAGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT50096 WP_002886901.1 NZ_CP009876:c1116789-1116547 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT50096 NZ_CP009876:c1116789-1116547 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References