Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 526021..526537 Replicon chromosome
Accession NZ_CP009872
Organism Klebsiella pneumoniae subsp. pneumoniae strain KPNIH30

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag KPNIH30_RS02650 Protein ID WP_002886902.1
Coordinates 526253..526537 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag KPNIH30_RS02645 Protein ID WP_002886901.1
Coordinates 526021..526263 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KPNIH30_RS02630 522050..522790 + 741 WP_002886899.1 KDGP aldolase family protein -
KPNIH30_RS02635 522856..524010 + 1155 WP_002886900.1 lactonase family protein -
KPNIH30_RS02640 524033..525943 + 1911 WP_004152270.1 BglG family transcription antiterminator -
KPNIH30_RS02645 526021..526263 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KPNIH30_RS02650 526253..526537 + 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KPNIH30_RS02655 526541..527005 - 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KPNIH30_RS02660 527246..529384 - 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
KPNIH30_RS02670 529741..530484 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
KPNIH30_RS29960 530487..530660 - 174 WP_002886906.1 hypothetical protein -
KPNIH30_RS02680 530745..531053 + 309 WP_002886907.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T50076 WP_002886902.1 NZ_CP009872:526253-526537 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T50076 NZ_CP009872:526253-526537 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT50076 WP_002886901.1 NZ_CP009872:526021-526263 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT50076 NZ_CP009872:526021-526263 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References