50039

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 12265..12908 Replicon plasmid pECO-824
Accession NZ_CP009860
Organism Escherichia coli strain ECONIH1

Toxin (Protein)


Gene name vagD Uniprot ID C7S9Y5
Locus tag ECONIH1_RS26485 Protein ID WP_001034046.1
Coordinates 12492..12908 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID V0SR71
Locus tag ECONIH1_RS26480 Protein ID WP_001261278.1
Coordinates 12265..12495 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECONIH1_RS26450 7776..8081 - 306 WP_001159868.1 type II toxin-antitoxin system toxin CcdB -
ECONIH1_RS26455 8083..8301 - 219 WP_000813634.1 type II toxin-antitoxin system antitoxin CcdA -
ECONIH1_RS26460 8868..9380 + 513 WP_000151784.1 hypothetical protein -
ECONIH1_RS26465 9414..10547 - 1134 WP_001542067.1 DUF3800 domain-containing protein -
ECONIH1_RS26470 10714..11487 - 774 WP_000905949.1 hypothetical protein -
ECONIH1_RS26475 11500..12000 - 501 WP_000528931.1 hypothetical protein -
ECONIH1_RS26480 12265..12495 + 231 WP_001261278.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
ECONIH1_RS26485 12492..12908 + 417 WP_001034046.1 type II toxin-antitoxin system VapC family toxin Toxin
ECONIH1_RS26490 12953..16747 - 3795 WP_001144732.1 hypothetical protein -
ECONIH1_RS26495 17128..17358 + 231 WP_001261286.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
ECONIH1_RS26500 17355..17771 + 417 WP_001034044.1 type II toxin-antitoxin system VapC family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sitABCD / erm(B) / mph(A) / sul1 / qacE / aadA5 / blaCTX-M-15 iucA / iucB / iucC / iucD / iutA 1..121385 121385


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-53)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14978.31 Da        Isoelectric Point: 6.7113

>T50039 WP_001034046.1 NZ_CP009860:12492-12908 [Escherichia coli]
VNKIYMLDTNICSFIMREQPEAVLKNLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCARLDAILPWDRA
AVDATTEVKVALRLAGTPIGPNDTAIAGHAIATGAILVTNNVREFERVPGLVLEDWAG

Download         Length: 417 bp

>T50039 NZ_CP009860:12492-12908 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAGCCTGAAGCAGTGCTTAAGAATCT
GGAGCAGGCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGCGCCACCGGTC
CAAAGGCATCGCCACGCCACGTGCAGCTGGTTGACGCGTTCTGCGCCCGTCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGATGCAACCACGGAGGTTAAGGTGGCGCTGCGCCTCGCCGGCACGCCGATCGGTCCAAACGACACGGCGATCGC
CGGGCACGCCATCGCCACCGGGGCAATACTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTGCCTGGACTGGTACTGG
AAGACTGGGCAGGATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8853.07 Da        Isoelectric Point: 4.6437

>AT50039 WP_001261278.1 NZ_CP009860:12265-12495 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDRIILRPLRPSWSSFLELEKADPGFMTEREDVVCDEGRFNL

Download         Length: 231 bp

>AT50039 NZ_CP009860:12265-12495 [Escherichia coli]
ATGAGAACCGTATCTATTTTCAAAAATGGCAATAACCGCGCGATCCGTCTGCCCCGCGATCTGGATTTTGAGGGGGTGAG
TGAGCTGGAGATTGTACGGGAAGGGGACAGAATCATTCTGCGTCCCCTCCGCCCGAGCTGGAGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGGCTTTATGACGGAACGCGAGGACGTTGTCTGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9NXF9

Antitoxin

Source ID Structure
AlphaFold DB V0SR71

References