Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3518377..3519212 Replicon chromosome
Accession NZ_CP009859
Organism Escherichia coli strain ECONIH1

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0A1A9A5
Locus tag ECONIH1_RS17470 Protein ID WP_001564063.1
Coordinates 3518835..3519212 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0A1AEL8
Locus tag ECONIH1_RS17465 Protein ID WP_038432125.1
Coordinates 3518377..3518745 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECONIH1_RS17425 3514036..3514716 + 681 WP_001278649.1 WYL domain-containing protein -
ECONIH1_RS17430 3514867..3515544 + 678 WP_001564058.1 hypothetical protein -
ECONIH1_RS17435 3515550..3515783 + 234 WP_001278293.1 DUF905 family protein -
ECONIH1_RS17440 3515873..3516691 + 819 WP_001175165.1 DUF945 domain-containing protein -
ECONIH1_RS17445 3516957..3517436 + 480 WP_001564060.1 antirestriction protein -
ECONIH1_RS17450 3517452..3517928 + 477 WP_021553055.1 RadC family protein -
ECONIH1_RS17455 3517993..3518214 + 222 WP_000692345.1 DUF987 domain-containing protein -
ECONIH1_RS17465 3518377..3518745 + 369 WP_038432125.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
ECONIH1_RS17470 3518835..3519212 + 378 WP_001564063.1 TA system toxin CbtA family protein Toxin
ECONIH1_RS31770 3519209..3519358 + 150 Protein_3321 hypothetical protein -
ECONIH1_RS31300 3519437..3519631 + 195 WP_024181941.1 DUF957 domain-containing protein -
ECONIH1_RS28140 3519716..3520558 + 843 Protein_3323 DUF4942 domain-containing protein -
ECONIH1_RS17490 3520900..3521070 + 171 Protein_3324 IS110 family transposase -
ECONIH1_RS17495 3521881..3522864 + 984 WP_001361242.1 KpsF/GutQ family sugar-phosphate isomerase -
ECONIH1_RS17500 3522936..3524084 + 1149 WP_000905920.1 capsule polysaccharide export inner-membrane protein KpsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - papX 3455391..3520685 65294
- flank IS/Tn - - 3520966..3521070 104


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14094.09 Da        Isoelectric Point: 7.8045

>T50027 WP_001564063.1 NZ_CP009859:3518835-3519212 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRSNYRTVNNITRGKHPEAKQ

Download         Length: 378 bp

>T50027 NZ_CP009859:3518835-3519212 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGCGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGTACTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGTCTGATGACCCGCAG
CAACTACAGAACGGTAAATAACATTACCCGGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13569.31 Da        Isoelectric Point: 7.0369

>AT50027 WP_038432125.1 NZ_CP009859:3518377-3518745 [Escherichia coli]
VSDTLSGTTHPDDNHDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGNRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT50027 NZ_CP009859:3518377-3518745 [Escherichia coli]
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTAACAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A1A9A5

Antitoxin

Source ID Structure
AlphaFold DB A0A0A1AEL8

References