Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
Location | 58615..59165 | Replicon | chromosome |
Accession | NZ_CP009859 | ||
Organism | Escherichia coli strain ECONIH1 |
Toxin (Protein)
Gene name | ccdB | Uniprot ID | S1PDG4 |
Locus tag | ECONIH1_RS00290 | Protein ID | WP_001160966.1 |
Coordinates | 58851..59165 (+) | Length | 105 a.a. |
Antitoxin (Protein)
Gene name | ccdA | Uniprot ID | S1NMQ0 |
Locus tag | ECONIH1_RS00285 | Protein ID | WP_000125568.1 |
Coordinates | 58615..58848 (+) | Length | 78 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
ECONIH1_RS00255 | 53690..53977 | + | 288 | WP_000203741.1 | ferredoxin-like protein FixX | - |
ECONIH1_RS00260 | 54035..55366 | + | 1332 | WP_001183201.1 | MFS transporter | - |
ECONIH1_RS00265 | 55474..56004 | + | 531 | WP_000600732.1 | glutathione-regulated potassium-efflux system oxidoreductase KefF | - |
ECONIH1_RS00270 | 55997..57859 | + | 1863 | WP_022645165.1 | glutathione-regulated potassium-efflux system protein KefC | - |
ECONIH1_RS00280 | 58050..58529 | + | 480 | WP_000624375.1 | type 3 dihydrofolate reductase | - |
ECONIH1_RS00285 | 58615..58848 | + | 234 | WP_000125568.1 | type II toxin-antitoxin system CcdA family antitoxin | Antitoxin |
ECONIH1_RS00290 | 58851..59165 | + | 315 | WP_001160966.1 | CcdB family protein | Toxin |
ECONIH1_RS00295 | 59162..60010 | - | 849 | WP_000257195.1 | bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH | - |
ECONIH1_RS00300 | 60017..60394 | - | 378 | WP_000610901.1 | Co2+/Mg2+ efflux protein ApaG | - |
ECONIH1_RS00305 | 60397..61218 | - | 822 | WP_001065381.1 | 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA | - |
ECONIH1_RS00310 | 61215..62204 | - | 990 | WP_000241224.1 | 4-hydroxythreonine-4-phosphate dehydrogenase PdxA | - |
ECONIH1_RS00315 | 62204..63490 | - | 1287 | WP_000800457.1 | peptidylprolyl isomerase SurA | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 105 a.a. Molecular weight: 11711.72 Da Isoelectric Point: 9.0851
>T50006 WP_001160966.1 NZ_CP009859:58851-59165 [Escherichia coli]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI
Download Length: 315 bp
>T50006 NZ_CP009859:58851-59165 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATCGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAATC
CAATCCTTTTACTGGTAGATGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCACACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATCGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAATC
CAATCCTTTTACTGGTAGATGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCACACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA
Antitoxin
Download Length: 78 a.a. Molecular weight: 8560.55 Da Isoelectric Point: 5.8062
>AT50006 WP_000125568.1 NZ_CP009859:58615-58848 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENTEAIAALNQLADETGCFSDEYRSF
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENTEAIAALNQLADETGCFSDEYRSF
Download Length: 234 bp
>AT50006 NZ_CP009859:58615-58848 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACA
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACA
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829G815 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829GEF2 |