Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 4500972..4501618 Replicon chromosome
Accession NZ_CP009840
Organism Yersinia pestis A1122

Toxin (Protein)


Gene name hicA Uniprot ID A0A3G5L3F2
Locus tag CH57_RS20945 Protein ID WP_002214976.1
Coordinates 4501436..4501618 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0U1R391
Locus tag CH57_RS20940 Protein ID WP_002211129.1
Coordinates 4500972..4501391 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH57_RS20920 4496043..4497038 + 996 WP_002211125.1 substrate-binding domain-containing protein -
CH57_RS20925 4497104..4498681 + 1578 WP_002211126.1 sugar ABC transporter ATP-binding protein -
CH57_RS20930 4498684..4499706 + 1023 WP_002214974.1 ABC transporter permease -
CH57_RS20935 4499755..4500714 + 960 WP_002211128.1 sugar kinase -
CH57_RS20940 4500972..4501391 - 420 WP_002211129.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CH57_RS20945 4501436..4501618 - 183 WP_002214976.1 type II toxin-antitoxin system HicA family toxin Toxin
CH57_RS20950 4501825..4502607 - 783 WP_002211130.1 flagellar type III secretion system protein FliR -
CH57_RS20955 4502610..4502879 - 270 WP_002211131.1 flagellar biosynthesis protein FliQ -
CH57_RS20960 4502985..4503725 - 741 WP_002220494.1 flagellar type III secretion system pore protein FliP -
CH57_RS20965 4503806..4504342 - 537 WP_002211133.1 flagellar biosynthetic protein FliO -
CH57_RS20970 4504342..4504758 - 417 WP_002211134.1 flagellar motor switch protein FliN -
CH57_RS20975 4504755..4505756 - 1002 WP_002211135.1 flagellar motor switch protein FliM -
CH57_RS20980 4505762..4506232 - 471 WP_002227961.1 flagellar basal body-associated protein FliL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-131)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6783.99 Da        Isoelectric Point: 10.8877

>T49958 WP_002214976.1 NZ_CP009840:c4501618-4501436 [Yersinia pestis A1122]
VKSSELIKLLETNGWKLMRVKGSHHQFKHPDFAAVITVPHPKKDVKPGTLRQILKDANLS

Download         Length: 183 bp

>T49958 NZ_CP009840:c4501618-4501436 [Yersinia pestis A1122]
GTGAAAAGTTCGGAGCTGATAAAACTGCTCGAAACAAATGGTTGGAAGTTGATGAGAGTTAAAGGCAGTCATCATCAATT
CAAACATCCTGATTTCGCGGCAGTCATAACAGTACCGCATCCCAAAAAGGATGTTAAACCGGGAACCCTCCGGCAAATTC
TGAAAGATGCAAACCTTAGTTAA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15549.42 Da        Isoelectric Point: 4.7731

>AT49958 WP_002211129.1 NZ_CP009840:c4501391-4500972 [Yersinia pestis A1122]
MAIYPAYVHVDNDGSASGYFPDVKGCIFAINAGEDLFAEASSALDAHFEALVSEGIEIPEAHDMPYHVYRNPCDYADGGQ
WYNVNIDMSKYDGKVERINVTLPHRLIHQIDTIVKVRPEYASRSNFLAEAARKELQKLA

Download         Length: 420 bp

>AT49958 NZ_CP009840:c4501391-4500972 [Yersinia pestis A1122]
ATGGCTATCTATCCCGCCTATGTTCACGTTGATAATGATGGCTCGGCAAGCGGTTATTTCCCCGATGTCAAAGGCTGTAT
TTTTGCCATCAATGCCGGGGAGGATTTATTTGCAGAAGCATCAAGCGCCCTGGATGCACACTTTGAAGCTTTGGTGTCTG
AAGGTATCGAAATTCCTGAAGCTCATGACATGCCTTACCACGTTTACCGTAACCCATGCGATTACGCTGATGGCGGACAG
TGGTATAACGTGAATATTGATATGTCGAAATATGATGGAAAAGTTGAACGAATTAACGTCACTCTTCCGCACCGGCTGAT
TCATCAAATCGATACTATTGTTAAAGTGCGTCCCGAGTATGCCAGCCGAAGCAATTTTCTAGCCGAAGCAGCACGTAAAG
AATTACAGAAATTGGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G5L3F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1R391

References