Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1274441..1275061 Replicon chromosome
Accession NZ_CP009840
Organism Yersinia pestis A1122

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag CH57_RS06170 Protein ID WP_002208622.1
Coordinates 1274858..1275061 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q66DR4
Locus tag CH57_RS06165 Protein ID WP_002218472.1
Coordinates 1274441..1274809 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH57_RS06150 1272636..1272896 + 261 WP_002208617.1 type B 50S ribosomal protein L31 -
CH57_RS06155 1272912..1273055 + 144 WP_002208618.1 type B 50S ribosomal protein L36 -
CH57_RS06160 1273929..1274282 + 354 WP_002208619.1 hypothetical protein -
CH57_RS06165 1274441..1274809 + 369 WP_002218472.1 Hha toxicity modulator TomB Antitoxin
CH57_RS06170 1274858..1275061 + 204 WP_002208622.1 expression modulating protein YmoA Toxin
CH57_RS06175 1275949..1276338 + 390 WP_002208623.1 MGMT family protein -
CH57_RS06180 1276474..1276995 - 522 WP_002208624.1 lipoprotein -
CH57_RS06185 1277252..1278112 + 861 WP_002208625.1 acyl-CoA thioesterase II -
CH57_RS06190 1278372..1279661 - 1290 WP_002228344.1 ammonium transporter AmtB -
CH57_RS06195 1279701..1280039 - 339 WP_002208627.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T49947 WP_002208622.1 NZ_CP009840:1274858-1275061 [Yersinia pestis A1122]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T49947 NZ_CP009840:1274858-1275061 [Yersinia pestis A1122]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATCGATACGCTAGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGATGATGAACTGGAATTGTTTTACTCAGCTGCAGACCATCGCCTGGCTGAACTAACGATGAATAAGC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14215.00 Da        Isoelectric Point: 4.6121

>AT49947 WP_002218472.1 NZ_CP009840:1274441-1274809 [Yersinia pestis A1122]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWINDPTSAINLQLNDLIEHIASFVMSFKIKYPDGSQLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKEHLFRLFSGEYVCTLMKT

Download         Length: 369 bp

>AT49947 NZ_CP009840:1274441-1274809 [Yersinia pestis A1122]
ATGGATGAGTACTCGCCTAAGCGGCATGACATTGCCCAACTGAAGTTTCTATGTGAAAGCTTGTATGATGAAGGTATTGC
AACTCTTGGCGACAGCCATCATGGCTGGATAAATGACCCAACGTCGGCCATAAACCTTCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGGAAGCCAGCTTTCCGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGTAGTTATGGAATCAATGATCCTGAATTGCGTCGCTGGCAGAAAACCAAAGAGCATTT
ATTCAGACTTTTCTCAGGGGAATACGTATGTACCCTGATGAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB Q66DR4

References