Detailed information of TA system TA049946

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /COG5642-COG5654
• Location: 416219..417185
• Replicon: chromosome
• Accession: NZ_CP009840
• Organism: Yersinia pestis A1122

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A0E8XJV6
• Locus tag: CH57_RS02095
• Protein ID: WP_002210981.1
• Coordinates: 416727..417185 (+)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: Q66A69
• Locus tag: CH57_RS02090
• Protein ID: WP_002210982.1
• Coordinates: 416219..416665 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CH57_RS02070	411809..412783	-	975	WP_002210985.1	L-Ala-D/L-Glu epimerase	-
CH57_RS02075	412946..413449	+	504	WP_002210984.1	thiol peroxidase	-
CH57_RS02080	413702..414160	+	459	WP_002213775.1	IS200/IS605-like element IS1541B family transposase	-
CH57_RS02085	414307..415884	-	1578	WP_002210983.1	transcriptional regulator TyrR	-
CH57_RS02090	416219..416665	+	447	WP_002210982.1	DUF2384 domain-containing protein	Antitoxin
CH57_RS02095	416727..417185	+	459	WP_002210981.1	RES family NAD+ phosphorylase	Toxin
CH57_RS02100	417195..418256	-	1062	WP_002210980.1	YcjF family protein	-
CH57_RS02105	418253..419650	-	1398	WP_002210979.1	YcjX family protein	-
CH57_RS02110	419631..419873	-	243	WP_002216375.1	phage shock protein PspD	-
CH57_RS02115	419958..420317	-	360	WP_002210977.1	envelope stress response membrane protein PspC	-
CH57_RS02120	420317..420544	-	228	WP_002210976.1	envelope stress response membrane protein PspB	-
CH57_RS02125	420706..421371	-	666	WP_002210975.1	phage shock protein PspA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	413702..414160	458

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (2-147)

Antitoxin

• Antitoxin Xre (15-147)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 16994.38 Da
• Isoelectric Point: 4.8732

>T49946 WP_002210981.1 NZ_CP009840:416727-417185 [Yersinia pestis A1122]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSVGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Nucleotide

• Length: 459 bp

>T49946 NZ_CP009840:416727-417185 [Yersinia pestis A1122]
ATGACGCTATACCGCATTGTTATGCGCCGCTATCTTGCATCGGCATGGACTGGTTACGGCGCTGAAATCTATGGTGGTCG
TTGGAATCATAAAGGCCATGCTGCCATCTATTTAGCCAGCAGTATTTCATTGGCTATGCTCGAAACACTGGCACATATTC
AGGACAGTTCAACACTCAGCGAATTTGAATTATTCCAAATTGAAATCAGTGACAGCAGTATTATGTTGCTACAGCCGCAG
GACTGGCCCACGGATTGGCGTAGCGATCCGGCACCGGTGGCAACGATGGATGTCGGCACCGAGTGGCTGGAATCAGAATC
CTCGGTAGGCTTACTGGTCCCGTCCACGTTGGTGCCGTCAGAAAACAACCTACTGGTCAATCCTCATCACAAAGATTTTC
CAGCGTGTTTGGCCAGCGTCAAACCGCTCTCTTTTGTCTTTGATCCACGGTTAAAATAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16401.94 Da
• Isoelectric Point: 9.7155

>AT49946 WP_002210982.1 NZ_CP009840:416219-416665 [Yersinia pestis A1122]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Nucleotide

• Length: 447 bp

>AT49946 NZ_CP009840:416219-416665 [Yersinia pestis A1122]
ATGAGAGCGTACCGCCCAAACCCCGCGACTAAAATGGGAACGCTTTGGCGTGAAATTGGCTTACCCGCCAGCCGCGGCAC
GATATTGGTCGATAGTATCAAAATGGGGTTTTCTGTTGATGTTATCGACAGCATTCATTTATGGGCATCCATGCCTAAAG
CTGAAATATTACGTGCTACCGGTATCCCCAGCCGTAGCCTGACTCGCCGCCGCACACATGATGGCCGTTTTACGCCTGAA
GAAAGCGAGAGAATCGCACGTTTTGTCCGCGTAATGGATGCCGCTGTCGATTTGTTCGGCGGCGATAAAGGTAAAGCCAT
TACCTGGATGTCCACGCCCATCAAAGGATTGGGGTACCGCAGCCCAGACTCCTTACTGGAAACCGAAACTGGCGCACTGG
AAGTGTGTGATTTGATTGGTCGTTTGGAACACGGCGTCTTTACTTAA

Structures

Toxin

• AlphaFold DB: A0A0E8XJV6

Antitoxin

• AlphaFold DB: A0A0E8XFL1