Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3046157..3046775 Replicon chromosome
Accession NZ_CP009838
Organism Yersinia enterocolitica strain 2516-87

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag CH48_RS13790 Protein ID WP_002208622.1
Coordinates 3046157..3046360 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A7U7FKE5
Locus tag CH48_RS13795 Protein ID WP_005163463.1
Coordinates 3046407..3046775 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH48_RS13765 3041528..3041866 + 339 WP_002208627.1 P-II family nitrogen regulator -
CH48_RS13770 3041906..3043195 + 1290 WP_032904831.1 ammonium transporter AmtB -
CH48_RS13775 3043309..3044172 - 864 WP_005163474.1 acyl-CoA thioesterase II -
CH48_RS13780 3044433..3044963 + 531 WP_005163468.1 YbaY family lipoprotein -
CH48_RS13785 3045015..3045320 - 306 WP_005163466.1 MGMT family protein -
CH48_RS13790 3046157..3046360 - 204 WP_002208622.1 expression modulating protein YmoA Toxin
CH48_RS13795 3046407..3046775 - 369 WP_005163463.1 Hha toxicity modulator TomB Antitoxin
CH48_RS13800 3046933..3047286 - 354 WP_005163460.1 hypothetical protein -
CH48_RS13805 3048052..3048762 + 711 WP_013649453.1 ABC transporter ATP-binding protein -
CH48_RS13810 3048776..3049633 + 858 WP_005163445.1 metal ABC transporter permease -
CH48_RS13815 3049696..3050574 + 879 WP_013649455.1 metal ABC transporter substrate-binding protein -
CH48_RS13820 3050702..3050845 - 144 WP_002208618.1 type B 50S ribosomal protein L36 -
CH48_RS13825 3050861..3051121 - 261 WP_005163438.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T49935 WP_002208622.1 NZ_CP009838:c3046360-3046157 [Yersinia enterocolitica]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T49935 NZ_CP009838:c3046360-3046157 [Yersinia enterocolitica]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATTGATACATTGGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGACGATGAGCTGGAATTGTTTTACTCAGCAGCAGACCACCGCTTAGCTGAACTCACAATGAATAAAC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14192.90 Da        Isoelectric Point: 4.3377

>AT49935 WP_005163463.1 NZ_CP009838:c3046775-3046407 [Yersinia enterocolitica]
MDEYSPKRHDVAQLKFLCESLYDEGIATLGDSHHGWVNDPTSAVNLQLNDLIEHIASFVMSFKIKYPDDGDLSELVEEYL
DDTYTLFSSYGINDPELQRWQKTKERLFRLFSGEYICTLMKT

Download         Length: 369 bp

>AT49935 NZ_CP009838:c3046775-3046407 [Yersinia enterocolitica]
ATGGATGAGTACTCACCTAAGCGGCATGACGTTGCCCAATTGAAGTTCCTGTGCGAGAGTTTGTATGATGAAGGCATTGC
TACCCTTGGTGATAGCCATCATGGCTGGGTAAATGATCCAACTTCAGCCGTAAACCTGCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGACGGCGACCTTTCAGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGCAGTTACGGAATCAATGATCCGGAATTGCAGCGCTGGCAAAAAACTAAAGAGCGTTT
ATTCAGACTTTTCTCAGGGGAATACATCTGTACCCTGATGAAAACTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
PDB 2MN2
AlphaFold DB A0A7U7FKE5

References