Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2316022..2317651 Replicon chromosome
Accession NZ_CP009838
Organism Yersinia enterocolitica strain 2516-87

Toxin (Protein)


Gene name hipA Uniprot ID A0A7U7IQ60
Locus tag CH48_RS10520 Protein ID WP_005165219.1
Coordinates 2316022..2317350 (-) Length 443 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A7U7FJW4
Locus tag CH48_RS10525 Protein ID WP_005165217.1
Coordinates 2317352..2317651 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH48_RS10505 2311613..2311966 + 354 WP_005165225.1 MmcQ/YjbR family DNA-binding protein -
CH48_RS10510 2312025..2314856 - 2832 WP_013650522.1 excinuclease ABC subunit UvrA -
CH48_RS10515 2315385..2315933 + 549 WP_005165221.1 single-stranded DNA-binding protein SSB1 -
CH48_RS10520 2316022..2317350 - 1329 WP_005165219.1 type II toxin-antitoxin system HipA family toxin Toxin
CH48_RS10525 2317352..2317651 - 300 WP_005165217.1 helix-turn-helix transcriptional regulator Antitoxin
CH48_RS10530 2317946..2318617 + 672 WP_013650521.1 glutathione S-transferase -
CH48_RS10535 2318978..2320345 + 1368 WP_005165212.1 NCS2 family permease -
CH48_RS10540 2320555..2322204 + 1650 WP_020282670.1 Na+/H+ antiporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(8-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-66)


Sequences

Toxin        


Download         Length: 443 a.a.        Molecular weight: 49925.93 Da        Isoelectric Point: 6.8736

>T49933 WP_005165219.1 NZ_CP009838:c2317350-2316022 [Yersinia enterocolitica]
MARRIQRLNIWMNGQHVGYWEKNRGEESLVYAQEWLANEQGRPLSLSLPFTANNQVYRGNIVRDYFDNLLPDSDDIRRRL
ATKYHADSINPFDLLFELGRDCVGAIQLLTDDAPPSDLFSIQQQPLTESDVARILRNSLSDNAFVRPEHDEDLRLSIAGA
QEKTALLFHDNRWCLPLGSTPTTHIFKLPLGLVGNMQADMRTSVENEWLCAKILASYNLPVASCEIGQFEDQKALIVERF
DRRLSRDKSWIVRLPQEDMCQATGTSPLKKYQMDGGPSITTIMEILSGSDNASEDRNVFFKAQIIFWLLAATDGHAKNFS
IAHLPGSRYHLTPLYDVLSTHPIIGSGRNQIAVQKSKLAMAVRGSKNYYLINQIQRRHWRKQAEFVGLGAIQADTIIDEI
IAATPRVITQVQAQLPANFPADLAEKILTGLHKQCEKISAML

Download         Length: 1329 bp

>T49933 NZ_CP009838:c2317350-2316022 [Yersinia enterocolitica]
ATGGCTCGTCGCATTCAACGGCTCAATATCTGGATGAATGGTCAGCACGTTGGCTATTGGGAAAAAAATCGAGGCGAAGA
ATCGCTGGTTTATGCCCAAGAATGGTTAGCAAACGAACAAGGCCGACCGCTATCATTATCATTGCCTTTCACTGCCAATA
ATCAGGTTTATAGAGGCAATATTGTCCGGGACTATTTTGATAATTTATTACCCGATAGCGATGATATCCGGCGACGTCTG
GCAACTAAATACCACGCTGACAGCATTAACCCTTTCGATCTATTGTTTGAATTAGGAAGAGATTGTGTCGGTGCAATACA
ATTGCTAACTGATGATGCTCCTCCCTCTGATCTATTCTCAATTCAACAACAACCACTAACAGAAAGCGATGTGGCTCGCA
TTCTACGAAACTCATTATCTGACAATGCATTTGTGCGCCCTGAACACGATGAGGATCTCAGATTGTCTATCGCAGGGGCA
CAAGAAAAAACAGCTCTTTTGTTTCACGACAACCGATGGTGCCTCCCATTGGGCAGCACTCCCACCACCCATATCTTCAA
ACTTCCGTTGGGCTTAGTCGGCAATATGCAAGCTGATATGAGGACCTCGGTTGAAAATGAATGGCTGTGTGCAAAAATTC
TGGCAAGTTATAACTTACCGGTCGCCAGTTGTGAAATTGGCCAGTTTGAAGACCAAAAAGCATTGATTGTTGAACGTTTT
GACCGACGTTTATCGCGTGACAAGAGTTGGATCGTCAGATTACCGCAAGAAGATATGTGCCAGGCCACTGGGACTTCTCC
CTTAAAAAAATATCAAATGGATGGTGGCCCCAGTATTACCACCATAATGGAGATTTTGAGTGGTTCGGATAATGCCAGTG
AAGACAGAAACGTCTTCTTTAAAGCACAGATTATTTTCTGGTTATTGGCCGCAACTGATGGACATGCAAAAAACTTTAGC
ATTGCTCATCTCCCCGGGAGTCGTTATCACCTCACGCCACTTTATGACGTGTTATCAACCCATCCGATTATCGGCTCGGG
TCGTAATCAGATTGCGGTTCAAAAATCCAAGTTAGCGATGGCGGTAAGAGGGAGTAAAAATTACTATTTGATTAACCAGA
TCCAACGCCGTCATTGGCGAAAACAGGCAGAATTTGTTGGACTAGGAGCGATTCAAGCTGACACTATTATCGATGAAATA
ATTGCCGCAACCCCACGGGTTATCACACAAGTACAAGCTCAACTTCCGGCTAATTTTCCTGCTGACTTAGCAGAGAAAAT
CCTTACTGGCCTTCATAAACAATGTGAAAAAATCTCGGCAATGCTTTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11141.78 Da        Isoelectric Point: 8.5374

>AT49933 WP_005165217.1 NZ_CP009838:c2317651-2317352 [Yersinia enterocolitica]
MDYPIKILSQLRPTLIGFRKNKGLTQASLAQLLGITQQSYAKLEADPTSASVERLFKVLQLLDVELILSEKKNASAHPNK
THQPEQSQTIDLPSKQEDW

Download         Length: 300 bp

>AT49933 NZ_CP009838:c2317651-2317352 [Yersinia enterocolitica]
ATGGACTATCCCATTAAAATTTTGAGTCAATTACGCCCGACGTTGATTGGTTTTCGAAAAAATAAAGGGCTGACTCAGGC
CAGCCTGGCACAACTGTTAGGAATCACCCAGCAGTCCTATGCAAAGCTTGAAGCTGATCCCACCTCGGCCAGTGTTGAAC
GGCTTTTTAAAGTATTACAACTTTTAGACGTAGAACTGATCCTTAGTGAGAAAAAAAACGCCAGCGCGCATCCCAATAAA
ACCCACCAGCCAGAACAAAGCCAGACGATAGATTTACCGTCAAAACAAGAGGATTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IQ60

Antitoxin

Source ID Structure
AlphaFold DB A0A7U7FJW4

References