Detailed information of TA system TA049925

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-CC2985
• Location: 27423..27957
• Replicon: plasmid pCD
• Accession: NZ_CP009837
• Organism: Yersinia enterocolitica strain 2516-87

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: CH48_RS00170
• Protein ID: WP_013749473.1
• Coordinates: 27658..27957 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: P0C2N3
• Locus tag: CH48_RS00165
• Protein ID: WP_005176524.1
• Coordinates: 27423..27665 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CH48_RS00145	23047..23265	+	219	WP_013749479.1	hypothetical protein	-
CH48_RS00150	23326..23796	-	471	WP_010891240.1	hypothetical protein	-
CH48_RS00155	24412..25578	+	1167	WP_010891239.1	plasmid-partitioning protein SopA	-
CH48_RS00160	25575..26540	+	966	WP_010891238.1	ParB/RepB/Spo0J family plasmid partition protein	-
CH48_RS22065	26965..27257	+	293	Protein_31	IS6 family transposase	-
CH48_RS00165	27423..27665	+	243	WP_005176524.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
CH48_RS00170	27658..27957	+	300	WP_013749473.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CH48_RS00175	28097..28756	-	660	WP_010891237.1	type III secretion system effector GTPase activator YopE	-
CH48_RS00180	28949..29341	+	393	WP_010891236.1	type III secretion system chaperone SycE/YerA	-
CH48_RS22070	29576..30748	+	1173	Protein_36	IS3 family transposase	-
CH48_RS00195	30952..31377	+	426	WP_010891235.1	type III secretion system chaperone SycH	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	yopO/ypkA / yadA / yopE / sycE/yerA / sycH / yopH / lcrQ/yscM / yscL / yscK / ylpB/yscJ / lcrO/yscI / yopR/yscH/lcrP / yscG / yscF / yscE / yscD / yscC / yscB / virG/yscW / yscU / yscT / yscS / yscR / yscQ / yscO / yscN / yscN / lcrE/yopN / tyeA / sycN / yscX / yscY / yscV/lcrD / lcrR / lcrG / lcrV / sycD/lcrH / yopB / yopD / yopM / sycT / yopT / yopK/yopQ / yopJ/yopP	1..69701	69701
	-	flank	IS/Tn	-	-	30123..30626	503

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• Antitoxin ParD (1-79)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11663.26 Da
• Isoelectric Point: 5.5497

>T49925 WP_013749473.1 NZ_CP009837:27658-27957 [Yersinia enterocolitica]
VYKLSELADEDIYNIASYTIRHFGVTQAKLYHENLAKVFELLAKNLELGAECNWICSDMRRFQYKKHGIYYITLSNDILI
SRVLHQSIDINAQDFPEYE

Nucleotide

• Length: 300 bp

>T49925 NZ_CP009837:27658-27957 [Yersinia enterocolitica]
GTGTATAAACTATCTGAACTGGCTGATGAGGATATTTATAATATTGCCAGTTATACTATCCGGCATTTCGGTGTGACTCA
GGCTAAGTTATACCATGAGAACTTGGCAAAGGTATTCGAGCTATTAGCTAAAAATCTAGAGTTAGGGGCTGAGTGTAACT
GGATTTGCTCTGACATGCGCCGTTTTCAGTATAAAAAGCACGGTATATACTATATAACGCTTAGCAATGATATTTTGATT
TCTCGAGTGCTGCATCAATCCATAGATATAAATGCTCAGGATTTTCCAGAGTATGAGTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8856.15 Da
• Isoelectric Point: 6.7232

>AT49925 WP_005176524.1 NZ_CP009837:27423-27665 [Yersinia enterocolitica]
MARVTSVTLGEHLTGFVGEMIQSGRYGNISEVLRDALRLMEAREQRVQHVRDMVLAGTNAPVSHRLMDEIFSAAVKDTSV

Nucleotide

• Length: 243 bp

>AT49925 NZ_CP009837:27423-27665 [Yersinia enterocolitica]
ATGGCTCGCGTAACCAGCGTAACACTTGGAGAGCATTTGACAGGTTTTGTGGGGGAAATGATTCAGTCTGGTCGTTATGG
CAATATATCAGAAGTGCTTCGTGATGCCTTAAGGCTAATGGAAGCACGTGAACAGCGTGTTCAACATGTACGCGATATGG
TGCTTGCAGGAACAAACGCACCTGTGAGCCATCGCTTAATGGATGAAATTTTTTCTGCTGCGGTGAAAGATACTAGTGTA
TAA

Structures

Antitoxin

• AlphaFold DB: A1JUB1