49924

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/Tad-HTH_37
Location 2633317..2634017 Replicon chromosome
Accession NZ_CP009832
Organism Burkholderia multivorans ATCC BAA-247

Toxin (Protein)


Gene name tad Uniprot ID B9BQB7
Locus tag NP80_RS24650 Protein ID WP_006405634.1
Coordinates 2633317..2633694 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID B9BQB8
Locus tag NP80_RS24655 Protein ID WP_006405635.1
Coordinates 2633694..2634017 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP80_RS24625 2628862..2629308 + 447 WP_006405630.1 VOC family protein -
NP80_RS24630 2629412..2630962 - 1551 WP_006398698.1 sodium:solute symporter family protein -
NP80_RS24635 2630959..2631192 - 234 WP_006398697.1 DUF3311 domain-containing protein -
NP80_RS24640 2631389..2632306 - 918 WP_006405631.1 spermidine synthase -
NP80_RS24645 2632534..2632788 + 255 WP_035488690.1 hypothetical protein -
NP80_RS24650 2633317..2633694 + 378 WP_006405634.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NP80_RS24655 2633694..2634017 + 324 WP_006405635.1 helix-turn-helix domain-containing protein Antitoxin
NP80_RS24660 2634040..2634531 - 492 WP_006409760.1 DNA-deoxyinosine glycosylase -
NP80_RS24665 2634528..2635142 - 615 WP_006398690.1 chorismate lyase -
NP80_RS24670 2635151..2637049 - 1899 WP_006409758.1 molecular chaperone HtpG -
NP80_RS24675 2637208..2638668 - 1461 WP_006405639.1 PLP-dependent aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(23-114)

Antitoxin

Cro/C1-type helix-turn-helix domain

(30-85)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13564.63 Da        Isoelectric Point: 9.7722

>T49924 WP_006405634.1 NZ_CP009832:2633317-2633694 [Burkholderia multivorans ATCC BAA-247]
MGINSSMVPYTKPLYWLGSARKHLKAMPEAVQDTFGYALYLAQTGGKHDQAKPLRGLGSAGVLEVVESEDSGTYRAVYTV
KLGGAVYVLHCFQKKSCRGIATPKPDIELVRARLRAAEAHANGEK

Download         Length: 378 bp

>T49924 NZ_CP009832:2633317-2633694 [Burkholderia multivorans ATCC BAA-247]
ATGGGTATAAATTCATCGATGGTTCCGTACACCAAACCGCTCTACTGGCTCGGCTCGGCACGCAAGCACTTGAAAGCGAT
GCCCGAAGCGGTACAGGACACGTTCGGCTATGCGCTGTATCTGGCCCAGACGGGAGGAAAGCACGATCAGGCCAAGCCGT
TGAGGGGTCTCGGATCGGCCGGCGTACTCGAGGTCGTGGAGTCGGAGGACAGCGGCACGTACCGGGCGGTCTATACGGTG
AAACTCGGTGGCGCCGTCTATGTGCTGCACTGTTTCCAGAAGAAATCGTGCCGCGGTATCGCTACGCCGAAGCCGGACAT
CGAACTGGTTCGCGCGCGCCTGAGGGCAGCCGAAGCACACGCAAATGGAGAAAAGTGA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11828.69 Da        Isoelectric Point: 8.0686

>AT49924 WP_006405635.1 NZ_CP009832:2633694-2634017 [Burkholderia multivorans ATCC BAA-247]
MIEIERGSGNVYADLGTPDAEEMRVKAQLAAKIAEIIKTRKWTQQHAARLLGMTQPKLSNMLRGQFRGVSEAKMLDCLAK
LGRDVQIVVGPDRHSETEGHIEVVFAA

Download         Length: 324 bp

>AT49924 NZ_CP009832:2633694-2634017 [Burkholderia multivorans ATCC BAA-247]
ATGATCGAAATCGAACGGGGCAGCGGCAACGTCTACGCGGATCTTGGCACGCCCGACGCCGAAGAAATGCGCGTCAAGGC
TCAACTCGCCGCCAAGATCGCGGAGATCATCAAGACTCGCAAATGGACGCAGCAGCACGCAGCACGATTGCTCGGCATGA
CGCAACCGAAGCTATCGAACATGCTGCGCGGGCAGTTTCGCGGTGTAAGCGAAGCGAAGATGCTCGACTGTCTCGCCAAG
CTCGGGCGCGATGTACAGATCGTCGTAGGACCGGACCGTCATTCGGAAACCGAAGGACACATCGAGGTCGTGTTCGCTGC
CTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B9BQB7

Antitoxin

Source ID Structure
AlphaFold DB B9BQB8

References