Detailed information of TA system TA049922

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapC-vagC/VapC-VagC
• Location: 277896..278533
• Replicon: chromosome
• Accession: NZ_CP009832
• Organism: Burkholderia multivorans ATCC BAA-247

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A8E2UU98
• Locus tag: NP80_RS13725
• Protein ID: WP_035489546.1
• Coordinates: 278132..278533 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: A0A132EWB1
• Locus tag: NP80_RS13720
• Protein ID: WP_006408845.1
• Coordinates: 277896..278132 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NP80_RS13700	273057..273599	+	543	WP_006408276.1	hypothetical protein	-
NP80_RS13705	273770..274801	+	1032	WP_045594318.1	helix-turn-helix domain-containing protein	-
NP80_RS13710	274920..276008	-	1089	WP_006408279.1	hypothetical protein	-
NP80_RS13715	276005..277708	-	1704	WP_006408280.1	thiamine pyrophosphate-binding protein	-
NP80_RS13720	277896..278132	+	237	WP_006408845.1	hypothetical protein	Antitoxin
NP80_RS13725	278132..278533	+	402	WP_035489546.1	type II toxin-antitoxin system VapC family toxin	Toxin
NP80_RS13730	278655..280043	-	1389	WP_006408285.1	L-serine ammonia-lyase	-
NP80_RS13735	280070..281212	-	1143	WP_006408286.1	alginate lyase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-121)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 15035.28 Da
• Isoelectric Point: 5.7429

>T49922 WP_035489546.1 NZ_CP009832:278132-278533 [Burkholderia multivorans ATCC BAA-247]
MPRYMLDTNMCIYLMKNQPEQVARRFAQCYTGDVVMSAITYAELEYGVTLCTNPARERRNLAALIEDIPVAPFDVAAAQA
YGPIREATRERKKDHLDKLIGAHAVSLDVVLVTNNERDFASYPGLRLENWLIG

Nucleotide

• Length: 402 bp

>T49922 NZ_CP009832:278132-278533 [Burkholderia multivorans ATCC BAA-247]
ATGCCGCGCTACATGCTCGACACCAACATGTGCATCTATCTGATGAAGAACCAGCCGGAGCAGGTCGCGCGGCGTTTCGC
GCAGTGCTACACGGGGGACGTCGTCATGTCGGCGATCACCTATGCGGAACTCGAGTACGGCGTGACGCTATGCACCAATC
CTGCCCGCGAACGCCGCAATCTCGCCGCGCTGATCGAGGATATCCCGGTGGCGCCGTTCGACGTTGCGGCTGCGCAGGCA
TACGGCCCCATTCGAGAGGCGACGCGCGAACGCAAGAAGGATCATCTCGACAAGCTGATCGGCGCGCACGCCGTATCGCT
CGACGTCGTGCTGGTGACCAACAACGAGCGTGATTTCGCGAGTTATCCGGGCTTGAGGCTGGAGAACTGGCTGATCGGCT
AG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8915.00 Da
• Isoelectric Point: 5.8651

>AT49922 WP_006408845.1 NZ_CP009832:277896-278132 [Burkholderia multivorans ATCC BAA-247]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERVGDEIRIRPARRPLTGVLGKFAKFGPDFMAEGRGDQEQAEREGW

Nucleotide

• Length: 237 bp

>AT49922 NZ_CP009832:277896-278132 [Burkholderia multivorans ATCC BAA-247]
ATGCATACCACCCGGGTCTTCCGGAATGGCAACTCGCAGGCGGTGCGGATTCCTGCGGATCTTGCTTATGAGCGCAGCGA
TATCGAACTCGAAATCGAGCGTGTCGGTGACGAAATTCGCATCCGGCCTGCGCGGCGGCCGCTGACCGGCGTGCTCGGCA
AGTTCGCGAAATTCGGGCCCGATTTCATGGCCGAGGGGCGCGGCGATCAGGAACAGGCCGAGCGCGAGGGTTGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A132EWB1