Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1790650..1791239 Replicon chromosome
Accession NZ_CP009831
Organism Burkholderia multivorans ATCC BAA-247

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NP80_RS10095 Protein ID WP_006409935.1
Coordinates 1790650..1791069 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NP80_RS10100 Protein ID WP_174328801.1
Coordinates 1791066..1791239 (-) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP80_RS10070 1785747..1786541 + 795 WP_006409930.1 AraC family transcriptional regulator -
NP80_RS10075 1787032..1787982 + 951 WP_172488721.1 DMT family transporter -
NP80_RS10080 1788186..1788761 + 576 WP_006409927.1 hypothetical protein -
NP80_RS10085 1788855..1788989 - 135 WP_006409923.1 entericidin A/B family lipoprotein -
NP80_RS10090 1789222..1790517 + 1296 WP_035487510.1 aspartate carbamoyltransferase -
NP80_RS10095 1790650..1791069 - 420 WP_006409935.1 type II toxin-antitoxin system VapC family toxin Toxin
NP80_RS10100 1791066..1791239 - 174 WP_174328801.1 plasmid stability protein Antitoxin
NP80_RS10105 1791523..1793769 + 2247 WP_006403070.1 TonB-dependent siderophore receptor -
NP80_RS10110 1793773..1794528 + 756 WP_006403069.1 sel1 repeat family protein -
NP80_RS10115 1794525..1795208 + 684 WP_006409924.1 Fe2+-dependent dioxygenase -
NP80_RS10120 1795222..1795425 - 204 WP_006403067.1 hypothetical protein -
NP80_RS31220 1796014..1796157 + 144 WP_006409932.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15146.38 Da        Isoelectric Point: 5.2157

>T49920 WP_006409935.1 NZ_CP009831:c1791069-1790650 [Burkholderia multivorans ATCC BAA-247]
MILVDTNVIFEPLRREPSAAVIEWLDAQNVETLFLAAISLAEMRFGVAALPEGRRRDWLEQSIEHRVVPVFRGRILPFDD
AAGKAYARIRAHARAVGNAIAPADGYIAATAEANGLIVATRDVAPFEAAGLRVIDPWAS

Download         Length: 420 bp

>T49920 NZ_CP009831:c1791069-1790650 [Burkholderia multivorans ATCC BAA-247]
ATGATCCTTGTCGATACGAACGTCATTTTCGAACCGCTGCGGCGCGAGCCGAGCGCGGCCGTGATCGAATGGCTCGACGC
CCAGAACGTCGAGACGCTGTTCCTGGCCGCGATCAGCCTCGCCGAAATGCGCTTCGGTGTCGCGGCGCTGCCGGAAGGAC
GCCGGCGGGACTGGCTGGAGCAAAGCATCGAGCATCGTGTCGTGCCGGTGTTTCGCGGCCGGATCCTGCCGTTCGACGAT
GCCGCGGGCAAAGCCTATGCGCGCATTCGTGCGCACGCCCGTGCCGTCGGCAACGCGATCGCGCCGGCCGACGGCTACAT
TGCCGCGACGGCCGAGGCGAACGGCCTGATCGTCGCGACGCGCGACGTCGCGCCGTTCGAGGCCGCGGGCCTGCGCGTGA
TCGATCCGTGGGCGTCATAG

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6298.07 Da        Isoelectric Point: 4.5184

>AT49920 WP_174328801.1 NZ_CP009831:c1791239-1791066 [Burkholderia multivorans ATCC BAA-247]
MHGRSTEAEVRDILEQAVLSEGRVKLGTLLAEIGREAGGVDLDIQRDKTRTDPMSFE

Download         Length: 174 bp

>AT49920 NZ_CP009831:c1791239-1791066 [Burkholderia multivorans ATCC BAA-247]
CTGCACGGGCGCAGTACCGAGGCAGAGGTGCGCGACATCCTCGAGCAGGCCGTGTTGTCGGAAGGGCGCGTGAAGCTGGG
AACCTTGCTGGCGGAAATCGGGCGGGAGGCAGGCGGTGTCGATCTCGACATCCAGCGTGACAAGACGCGAACCGACCCGA
TGAGCTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References