Detailed information of TA system TA049917

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 1355437..1355971
• Replicon: chromosome
• Accession: NZ_CP009831
• Organism: Burkholderia multivorans ATCC BAA-247

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: NP80_RS08290
• Protein ID: WP_006411826.1
• Coordinates: 1355672..1355971 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: B9B0C2
• Locus tag: NP80_RS08285
• Protein ID: WP_006397060.1
• Coordinates: 1355437..1355682 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NP80_RS08270	1350488..1352191	+	1704	WP_006411824.1	VRR-NUC domain-containing protein	-
NP80_RS08275	1352188..1354488	+	2301	WP_006411821.1	ATP-dependent DNA helicase	-
NP80_RS08280	1354527..1355297	-	771	WP_006403543.1	helix-turn-helix domain-containing protein	-
NP80_RS08285	1355437..1355682	+	246	WP_006397060.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
NP80_RS08290	1355672..1355971	+	300	WP_006411826.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
NP80_RS08295	1356080..1357381	-	1302	WP_006403538.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
NP80_RS08300	1357605..1358912	-	1308	WP_006411823.1	shikimate transporter	-
NP80_RS08305	1359267..1360394	+	1128	WP_006403536.1	VOC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-94)

Antitoxin

• Antitoxin ParD (1-80)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11585.15 Da
• Isoelectric Point: 9.3671

>T49917 WP_006411826.1 NZ_CP009831:1355672-1355971 [Burkholderia multivorans ATCC BAA-247]
MPVKARTVRLTPLAEADLEAIWSYTYKRWSLDQAERYIGELSAAFERLARRESVGWPSRAGGNYSRYLVGSHVVFYRETT
ETLDVIRVLHQRMDVDRHL

Nucleotide

• Length: 300 bp

>T49917 NZ_CP009831:1355672-1355971 [Burkholderia multivorans ATCC BAA-247]
ATGCCGGTTAAGGCGCGCACGGTACGCCTGACGCCGCTGGCGGAGGCCGACCTCGAGGCCATCTGGTCTTACACGTACAA
GCGCTGGTCGCTCGACCAGGCTGAGCGCTATATCGGCGAGCTGAGCGCGGCGTTCGAGCGGCTGGCGCGCCGGGAGTCGG
TAGGGTGGCCGAGCCGCGCGGGCGGCAACTATTCGCGGTACCTGGTCGGTTCGCACGTGGTGTTCTATCGGGAAACGACC
GAAACCCTTGACGTCATTCGCGTGCTGCACCAGCGGATGGATGTCGACCGACATCTGTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8662.73 Da
• Isoelectric Point: 6.4604

>AT49917 WP_006397060.1 NZ_CP009831:1355437-1355682 [Burkholderia multivorans ATCC BAA-247]
MARNTSISLGDHLTEFVDMQVASGRYGSASDVVRAGLRLLETQETELRALQEALKAGEASGTPAPFDSQAFLARMRAKHA
G

Nucleotide

• Length: 246 bp

>AT49917 NZ_CP009831:1355437-1355682 [Burkholderia multivorans ATCC BAA-247]
ATGGCACGAAATACATCGATCTCGCTGGGCGATCATCTGACCGAATTTGTCGACATGCAGGTCGCGTCCGGCCGCTACGG
CTCGGCTAGCGATGTCGTGCGCGCGGGCCTGCGCCTGCTCGAGACACAGGAAACCGAGCTGCGGGCGCTGCAGGAAGCGT
TGAAGGCGGGCGAGGCATCGGGCACACCGGCTCCGTTCGACAGCCAGGCGTTCCTGGCCCGGATGCGGGCCAAGCATGCC
GGTTAA

Structures

Antitoxin

• AlphaFold DB: B9B0C2