Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 643281..643901 Replicon chromosome
Accession NZ_CP009831
Organism Burkholderia multivorans ATCC BAA-247

Toxin (Protein)


Gene name relE Uniprot ID A0A0H3KJN2
Locus tag NP80_RS05185 Protein ID WP_012217495.1
Coordinates 643584..643901 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID B9B269
Locus tag NP80_RS05180 Protein ID WP_006398012.1
Coordinates 643281..643580 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP80_RS05155 638519..639790 + 1272 WP_006411366.1 Rieske 2Fe-2S domain-containing protein -
NP80_RS05160 639805..640293 + 489 WP_006398008.1 aromatic-ring-hydroxylating dioxygenase subunit beta -
NP80_RS05165 640311..640637 + 327 WP_006404219.1 non-heme iron oxygenase ferredoxin subunit -
NP80_RS05170 640627..641847 + 1221 WP_006411378.1 FAD-dependent oxidoreductase -
NP80_RS05175 641962..643248 + 1287 WP_035487943.1 DUF445 domain-containing protein -
NP80_RS05180 643281..643580 - 300 WP_006398012.1 putative addiction module antidote protein Antitoxin
NP80_RS05185 643584..643901 - 318 WP_012217495.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NP80_RS05190 644264..645904 + 1641 WP_006398015.1 acetolactate synthase large subunit -
NP80_RS05195 645933..647366 + 1434 WP_006404214.1 aldehyde dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(9-102)

Antitoxin

Uncharacterized protein HI1420

(4-96)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.94 Da        Isoelectric Point: 10.2349

>T49915 WP_012217495.1 NZ_CP009831:c643901-643584 [Burkholderia multivorans ATCC BAA-247]
MPYLAPTFSIRTTAVFDAWFAGLQDRTAKRRIQARIDRLSMGNLGNWKSVGSPVYEMRIDHGPGYRVYFVRRRTIWVVLL
CGGDKSTQRDDIRAAHAMLEHLDLE

Download         Length: 318 bp

>T49915 NZ_CP009831:c643901-643584 [Burkholderia multivorans ATCC BAA-247]
ATGCCTTACCTTGCTCCAACGTTCAGCATCCGGACGACCGCCGTGTTCGACGCGTGGTTTGCCGGCCTGCAGGACCGCAC
CGCGAAGCGCCGCATTCAGGCGCGCATCGATCGGCTGTCGATGGGCAATCTGGGCAACTGGAAGTCCGTCGGGTCGCCCG
TCTACGAGATGCGCATCGATCACGGCCCCGGCTATCGCGTGTACTTCGTGCGGCGGCGCACGATATGGGTCGTCCTGCTG
TGCGGCGGCGACAAATCCACGCAGCGCGACGACATTCGCGCCGCCCATGCGATGCTCGAGCATCTCGACCTGGAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10605.00 Da        Isoelectric Point: 6.6381

>AT49915 WP_006398012.1 NZ_CP009831:c643580-643281 [Burkholderia multivorans ATCC BAA-247]
MSKISTRPWDSAEHLKTDDDMAEYFEACLQEGGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAHA

Download         Length: 300 bp

>AT49915 NZ_CP009831:c643580-643281 [Burkholderia multivorans ATCC BAA-247]
ATGAGCAAGATCAGCACGCGGCCGTGGGATTCGGCCGAACACCTGAAGACCGACGACGACATGGCCGAGTATTTCGAAGC
TTGCCTCCAGGAAGGCGGCGACGATCCGGCATTCATCGCGCACGCGCTCGGCGTGATCGCGCGCGCCCGCGGCATGTCGC
AAGTCGCGCGCGATGCGGGGCTATCGCGCGAGGGGCTGTACAAGGCGCTGTCGCACGACGGCAATCCGAGCTTCGGCACG
ATCCTCAAAGTGATCAAGGCGCTCGGCCTGCAACTGCACGGCGCGAAAGCGCACGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3KJN2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3KTI5

References