Detailed information of TA system TA049912

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumAB/COG3657-dnstrm_HI1420
• Location: 1468657..1469249
• Replicon: chromosome
• Accession: NZ_CP009829
• Organism: Xylella fastidiosa strain 3124

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: Q9PD07
• Locus tag: XFC3_RS06755
• Protein ID: WP_010894094.1
• Coordinates: 1468657..1468953 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: -
• Locus tag: XFC3_RS06760
• Protein ID: WP_004085592.1
• Coordinates: 1468956..1469249 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
XFC3_RS06725	1464189..1464680	-	492	WP_171817079.1	glutathione peroxidase	-
XFC3_RS06730	1465179..1465340	+	162	WP_155641627.1	hypothetical protein	-
XFC3_RS06735	1465519..1466394	+	876	WP_023906641.1	ABC transporter ATP-binding protein	-
XFC3_RS06740	1466391..1467368	+	978	WP_023906642.1	hypothetical protein	-
XFC3_RS06745	1467610..1468056	+	447	WP_031336674.1	hypothetical protein	-
XFC3_RS06750	1468246..1468465	-	220	Protein_1317	tail fiber protein	-
XFC3_RS06755	1468657..1468953	+	297	WP_010894094.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
XFC3_RS06760	1468956..1469249	+	294	WP_004085592.1	putative addiction module antidote protein	Antitoxin
XFC3_RS06765	1469305..1469658	-	354	WP_010894092.1	hypothetical protein	-
XFC3_RS06770	1469655..1470296	-	642	WP_023906644.1	hypothetical protein	-
XFC3_RS06775	1470293..1471123	-	831	WP_023906645.1	hypothetical protein	-
XFC3_RS06780	1471120..1471437	-	318	WP_023906646.1	hypothetical protein	-
XFC3_RS06785	1471437..1472207	-	771	WP_023906647.1	hypothetical protein	-
XFC3_RS06790	1472557..1472811	-	255	WP_023906648.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1468657..1493484	24827

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (1-94)

Antitoxin

• Uncharacterized protein HI1420 (3-93)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11167.73 Da
• Isoelectric Point: 9.8173

>T49912 WP_010894094.1 NZ_CP009829:1468657-1468953 [Xylella fastidiosa]
MIELKQTDTFRKWREKLKDARARSAIASRLDRLAFGHVGDAEPVGKGVSELRINYGPGYRVYFQQRGDTIYLLLCGGDKG
LQARDIKTALHLSEQWSE

Nucleotide

• Length: 297 bp

>T49912 NZ_CP009829:1468657-1468953 [Xylella fastidiosa]
ATGATTGAATTGAAGCAGACTGACACCTTCCGCAAGTGGCGGGAGAAACTCAAGGATGCGCGCGCCCGCTCGGCCATCGC
CTCACGCCTCGACCGCTTGGCGTTCGGCCATGTCGGCGACGCCGAGCCAGTAGGGAAAGGTGTCAGCGAGCTTCGCATCA
ACTACGGCCCCGGTTACCGGGTGTATTTCCAGCAGCGTGGCGACACGATCTACTTGCTACTTTGCGGCGGTGACAAAGGA
TTACAAGCGCGTGACATCAAGACTGCGCTGCACCTCTCTGAACAATGGAGCGAATGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10246.59 Da
• Isoelectric Point: 5.6232

>AT49912 WP_004085592.1 NZ_CP009829:1468956-1469249 [Xylella fastidiosa]
MTEKLTSYDPAEDLTTDQAIADFMAAAFGTNDPAYVAHALGVVARAKGMTQIASQTGLSREQLYRSFSAEGNPTLRTTLA
VMKALGIELSAKPSGVH

Nucleotide

• Length: 294 bp

>AT49912 NZ_CP009829:1468956-1469249 [Xylella fastidiosa]
ATGACCGAGAAACTGACGAGCTACGATCCGGCCGAGGACTTGACCACTGACCAGGCCATCGCCGATTTCATGGCAGCCGC
GTTCGGGACGAACGATCCTGCCTACGTTGCCCACGCGCTAGGCGTCGTTGCCCGCGCCAAGGGCATGACGCAGATCGCCA
GCCAGACAGGGCTATCGCGCGAACAGCTCTACCGCTCGTTCAGTGCCGAGGGCAACCCGACGCTGCGCACGACATTAGCC
GTGATGAAGGCGCTAGGGATCGAGCTCTCTGCGAAACCGTCTGGTGTTCACTGA

Structures

Toxin

• AlphaFold DB: A0A1S0V711