Detailed information of TA system TA049910

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 1035506..1036068
• Replicon: chromosome
• Accession: NZ_CP009829
• Organism: Xylella fastidiosa strain 3124

Toxin (Protein)

• Gene name: parE
• Uniprot ID: Q9PBR6
• Locus tag: XFC3_RS04465
• Protein ID: WP_010894527.1
• Coordinates: 1035772..1036068 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q9PBR5
• Locus tag: XFC3_RS04460
• Protein ID: WP_010894528.1
• Coordinates: 1035506..1035784 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
XFC3_RS04435	1031606..1032412	+	807	WP_023906424.1	oxidoreductase	-
XFC3_RS04440	1032743..1033003	+	261	WP_023906425.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
XFC3_RS04445	1032990..1033271	+	282	WP_023906426.1	type II toxin-antitoxin system YafQ family toxin	-
XFC3_RS04450	1033689..1034723	-	1035	WP_023906427.1	serine protease	-
XFC3_RS04455	1034729..1034977	-	249	WP_199251119.1	transposase	-
XFC3_RS04460	1035506..1035784	+	279	WP_010894528.1	CopG family ribbon-helix-helix protein	Antitoxin
XFC3_RS04465	1035772..1036068	+	297	WP_010894527.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
XFC3_RS04470	1036725..1036967	+	243	WP_010894524.1	type II toxin-antitoxin system ParD family antitoxin	-
XFC3_RS04475	1036960..1037248	+	289	Protein_867	type II toxin-antitoxin system RelE/ParE family toxin	-
XFC3_RS04480	1037710..1038144	+	435	Protein_868	hypothetical protein	-
XFC3_RS04485	1038553..1039008	+	456	WP_010894521.1	hypothetical protein	-
XFC3_RS04490	1039005..1039277	+	273	WP_010894520.1	hypothetical protein	-
XFC3_RS04495	1039281..1039589	+	309	WP_010894519.1	type II toxin-antitoxin system RelE/ParE family toxin	-
XFC3_RS04500	1039698..1039967	+	270	WP_010894518.1	hypothetical protein	-
XFC3_RS04505	1040019..1040222	+	204	WP_023906434.1	hypothetical protein	-
XFC3_RS04510	1040216..1040751	+	536	Protein_874	recombinase family protein	-
XFC3_RS04515	1040781..1040990	-	210	WP_010894516.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11155.72 Da
• Isoelectric Point: 7.4670

>T49910 WP_010894527.1 NZ_CP009829:1035772-1036068 [Xylella fastidiosa]
MPRVIFAPEAILNIQRLRNFLHPKNTDAARRAGEAIMRGARMLGAQPHIGRPVDDMPDEYREWLIDFGDSGYVARYHIDG
DTVTILAVRHHKEVGYTS

Nucleotide

• Length: 297 bp

>T49910 NZ_CP009829:1035772-1036068 [Xylella fastidiosa]
ATGCCACGGGTGATCTTCGCTCCCGAAGCCATCCTGAACATTCAACGATTGCGGAATTTCCTGCATCCGAAGAACACCGA
TGCCGCAAGGCGGGCCGGTGAAGCCATCATGCGGGGTGCGCGGATGCTTGGAGCGCAGCCACATATCGGTCGTCCGGTTG
ATGATATGCCCGATGAGTACAGGGAATGGCTGATTGACTTCGGAGATAGCGGTTATGTGGCCCGCTACCACATTGATGGC
GATACCGTCACGATCTTGGCTGTTCGACACCATAAGGAAGTGGGATACACCAGCTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10772.08 Da
• Isoelectric Point: 5.6126

>AT49910 WP_010894528.1 NZ_CP009829:1035506-1035784 [Xylella fastidiosa]
MGMATSIKLDDELKGRVQHLADVRRRTSHWIMREAIAQYVEREEKRETFRQDTLKAWEEFQATGLHVTTEEVEKWLSSWG
TENELSAPVCHG

Nucleotide

• Length: 279 bp

>AT49910 NZ_CP009829:1035506-1035784 [Xylella fastidiosa]
ATGGGCATGGCAACCTCCATCAAGCTTGATGATGAGCTGAAAGGACGTGTGCAGCATCTGGCCGATGTTCGCCGCCGCAC
TTCGCACTGGATCATGCGCGAGGCGATCGCGCAGTACGTTGAGCGTGAGGAAAAGCGTGAGACGTTTCGGCAGGACACGC
TGAAGGCATGGGAAGAGTTTCAGGCGACCGGCCTGCACGTGACGACCGAAGAAGTCGAGAAGTGGCTTTCGAGTTGGGGC
ACTGAAAATGAATTGTCAGCGCCCGTATGCCACGGGTGA

Structures

Toxin

• AlphaFold DB: A0A1S0VAK4

Antitoxin

• AlphaFold DB: A0A1S0V821